Laxatives & Bowel Regulators

Norfloxacin (400mg) and Tinidazole (600mg) Tablets is a fixed-dose broad-spectrum antibacterial and antiprotozoal combination. Norfloxacin is a second-generation fluoroquinolone that inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV. Tinidazole is a second-generation nitroimidazole that causes DNA strand breakage in anaerobic bacteria and protozoa. Indicated for acute infectious diarrhea, amoebic dysentery (Entamoeba histolytica), mixed bacterial-protozoal enteritis, and giardiasis.

Bisacodyl Tablets (5mg) is an oral stimulant laxative on the WHO Model List of Essential Medicines. It acts locally on the colonic mucosa after passage through the small bowel, stimulating enteric intramural plexuses to induce mass peristalsis and promote fluid and electrolyte accumulation in the lumen. Onset of action is 6 to 12 hours. Indicated for short-term relief of occasional constipation and bowel prep prior to colonoscopy or abdominal surgery.

Furazolidone Tablets (100mg) is a synthetic nitrofuran broad-spectrum antimicrobial and antiprotozoal agent. It interferes with bacterial enzyme systems and DNA metabolism, displaying bactericidal activity against GI pathogens including Salmonella, Shigella, enteropathogenic E. coli, and protozoa such as Giardia lamblia. Indicated for bacterial diarrhea, enteritis, and giardiasis.

Lactic Acid Bacillus (Lactobacillus sporogenes / Bacillus coagulans 60 Million spores) and Multi-Strain Probiotic/Prebiotic Formulations (Bacillus mesentericus, Clostridium butyricum, L. sporogenes, Streptococcus faecalis) is an oral symbiotic gut flora supplement. Lactic acid-producing spores survive stomach acidity and colonize the intestinal brush border, lowering luminal pH, suppressing pathogenic coliforms, reinforcing epithelial tight junctions, and aiding digestion of lactose. Prebiotics feed beneficial commensals. Indicated for antibiotic-associated diarrhea, traveler's diarrhea, post-gastroenteritis dysbiosis, and irritable bowel syndrome.

Lactulose Solution (10g/15ml) is a non-absorbable synthetic disaccharide osmotic laxative and ammonia-lowering agent on the WHO Model List of Essential Medicines. In the colon, bacterial flora ferment lactulose into low-molecular-weight organic acids (lactic, acetic, and formic acids), lowering colonic pH. This osmotic effect draws water into the stool, stimulating peristalsis. In hepatic encephalopathy, acidification traps ammonia as non-absorbable ammonium ions (NH4+) and promotes nitrogen excretion by colonic bacteria. Indicated for chronic constipation and prevention/treatment of portal systemic hepatic encephalopathy.

Bacillus Clausii Spores Suspension (2 Billion spores per 5ml mini-bottles) is an oral spore-forming probiotic on the WHO Model List framework. Bacillus clausii spores are naturally resistant to gastric acid and bile; upon reaching the intestine, they germinate into metabolically active vegetative bacteria that synthesize B-complex vitamins, produce antimicrobial bacteriocins, stimulate mucosal secretor IgA, and competitively exclude pathogens. Demonstrates intrinsic multi-antibiotic resistance, allowing co-administration during antibiotic therapy. Indicated for treatment and prevention of intestinal dysbiosis, antibiotic-associated diarrhea, and acute infectious diarrhea in children and adults.

Liquid Paraffin (1.25ml/3.75ml), Milk of Magnesia (3.75ml/11.25ml), and Sodium Picosulphate (3.33mg) Suspension is a triple-action laxative combining a stool lubricant, an osmotic laxative, and a contact stimulant. Liquid paraffin softens and lubricates stools; Milk of Magnesia (magnesium hydroxide) draws water osmotically into the bowel lumen; and sodium picosulphate is activated by colonic sulfatases to stimulate myenteric peristalsis. Indicated for acute and chronic severe constipation, painful anorectal conditions (piles, anal fissures), and post-surgical bowel clearance.

Sodium Picosulphate Tablets (10mg) is an oral prodrug stimulant contact laxative on the WHO Model List framework. It passes unabsorbed through the stomach and small intestine to the colon, where bacterial sulfatases hydrolyze it to the active free diphenol metabolite (BHPM). This metabolite stimulates mucosal sensory nerve endings to induce strong colonic propulsive contractions within 6 to 12 hours. Indicated for short-term management of constipation and colon preparation prior to colonoscopy.

Loperamide Capsules (2mg) is a synthetic peripheral mu-opioid receptor agonist on the WHO Model List of Essential Medicines. It binds to opioid receptors in the circular and longitudinal muscle layers of the gut wall, inhibiting peristaltic activity, prolonging gastrointestinal transit time, increasing water and electrolyte absorption, and enhancing anal sphincter tone. Indicated for control and symptomatic relief of acute non-specific diarrhea and chronic diarrhea associated with inflammatory bowel disease or short bowel syndrome.

Sulfasalazine Gastro-Resistant / Delayed Release Tablets (500mg, 1000mg) is a synthetic azo-bonded conjugate of 5-aminosalicylic acid (5-ASA) and sulfapyridine on the WHO Model List of Essential Medicines. Bacteria in the colon cleave the azo bond via azoreductase enzymes, liberating 5-ASA to exert topical anti-inflammatory action on colonic mucosa, while absorbed sulfapyridine exerts systemic immunomodulatory effects. Indicated for induction and maintenance of remission in ulcerative colitis, active Crohn's disease, and disease-modifying antirheumatic drug (DMARD) therapy for rheumatoid arthritis.

Sulfasalazine Gastro-Resistant / Delayed Release Tablets (500mg, 1000mg) is a synthetic azo-bonded conjugate of 5-aminosalicylic acid (5-ASA) and sulfapyridine on the WHO Model List of Essential Medicines. Bacteria in the colon cleave the azo bond via azoreductase enzymes, liberating 5-ASA to exert topical anti-inflammatory action on colonic mucosa, while absorbed sulfapyridine exerts systemic immunomodulatory effects. Indicated for induction and maintenance of remission in ulcerative colitis, active Crohn's disease, and disease-modifying antirheumatic drug (DMARD) therapy for rheumatoid arthritis.

Lactulose Solution (10g/15ml) is a non-absorbable synthetic disaccharide osmotic laxative and ammonia-lowering agent on the WHO Model List of Essential Medicines. In the colon, bacterial flora ferment lactulose into low-molecular-weight organic acids (lactic, acetic, and formic acids), lowering colonic pH. This osmotic effect draws water into the stool, stimulating peristalsis. In hepatic encephalopathy, acidification traps ammonia as non-absorbable ammonium ions (NH4+) and promotes nitrogen excretion by colonic bacteria. Indicated for chronic constipation and prevention/treatment of portal systemic hepatic encephalopathy.

Mesalazine / Mesalamine (400mg, 500mg, 800mg, 1200mg Delayed Release / Prolonged Release Tablets) is an oral 5-aminosalicylic acid (5-ASA) anti-inflammatory agent on the WHO Model List of Essential Medicines. Formulated with pH-dependent (pH >= 7) enteric coatings or multi-matrix (MMX) core systems to bypass gastric degradation and deliver high local 5-ASA concentrations specifically to the terminal ileum and colon. Locally inhibits 5-lipoxygenase, reduces leukotriene B4 and pro-inflammatory prostaglandin synthesis, and scavenges free radicals without systemic corticosteroid toxicity. Indicated for induction and maintenance of clinical and endoscopic remission in mild-to-moderate ulcerative colitis.

Diphenoxylate Hydrochloride (2.5mg) and Atropine Sulphate (0.025mg) Tablets is a fixed-dose antidiarrheal combination on the WHO Model List framework. Diphenoxylate is a synthetic opioid receptor agonist structurally related to meperidine that slows intestinal motility, prolonging transit time and allowing increased fluid resorption. Subtherapeutic atropine sulphate is included specifically to deter deliberate abuse by causing unpleasant anticholinergic symptoms (dry mouth, tachycardia, flushing) if taken in excessive quantities. Indicated as adjunctive therapy in the management of acute or chronic diarrhea.

Lactitol (10g) and Ispaghula Husk (3.5g) Granules is a dual-action osmotic and bulk-forming laxative combination. Lactitol is a non-absorbable disaccharide sugar alcohol that is fermented by colonic bacteria into short-chain fatty acids, exerting an osmotic gradient that retains water in the lumen. Ispaghula (psyllium) is a hydrophilic mucilloid that swells upon hydration to form an emollient gelatinous mass, naturally increasing fecal mass and stimulating peristalsis. Indicated for chronic idiopathic constipation, painful defecation in hemorrhoids and anal fissures, and irritable bowel syndrome with constipation (IBS-C).

Lactic Acid Bacillus (Lactobacillus sporogenes / Bacillus coagulans 60 Million spores) and Multi-Strain Probiotic/Prebiotic Formulations (Bacillus mesentericus, Clostridium butyricum, L. sporogenes, Streptococcus faecalis) is an oral symbiotic gut flora supplement. Lactic acid-producing spores survive stomach acidity and colonize the intestinal brush border, lowering luminal pH, suppressing pathogenic coliforms, reinforcing epithelial tight junctions, and aiding digestion of lactose. Prebiotics feed beneficial commensals. Indicated for antibiotic-associated diarrhea, traveler's diarrhea, post-gastroenteritis dysbiosis, and irritable bowel syndrome.

Prucalopride Tablets (1mg, 2mg) is a first-in-class, high-affinity, selective serotonin 5-HT4 receptor agonist prokinetic. It stimulates 5-HT4 receptors on colonic intramural neurons, triggering giant migrating contractions that accelerate colonic transit without interacting with dopamine D2 receptors, 5-HT1, 5-HT2, or cardiac HERG potassium channels. Indicated for symptomatic treatment of chronic idiopathic constipation in adults in whom conventional laxatives fail to provide adequate relief.

Prucalopride Tablets (1mg, 2mg) is a first-in-class, high-affinity, selective serotonin 5-HT4 receptor agonist prokinetic. It stimulates 5-HT4 receptors on colonic intramural neurons, triggering giant migrating contractions that accelerate colonic transit without interacting with dopamine D2 receptors, 5-HT1, 5-HT2, or cardiac HERG potassium channels. Indicated for symptomatic treatment of chronic idiopathic constipation in adults in whom conventional laxatives fail to provide adequate relief.

Racecadotril (100mg Capsules; 10mg, 15mg, 30mg Sachets) is an oral peripheral enkephalinase inhibitor antisecretory antidiarrheal on the WHO Model List framework. It is a prodrug hydrolyzed to thiorphan, which inhibits enkephalinase, sparing endogenous opioid enkephalins in the gut. This selectively reduces intestinal hypersecretion of water and electrolytes induced by cholera toxin, rotavirus, or inflammatory enterotoxins without delaying bowel transit or causing secondary constipation or bacterial overgrowth. Indicated for complementary symptomatic treatment of acute watery diarrhea in adults (capsules) and infants/children >3 months (sachets) alongside Oral Rehydration Therapy (ORS).

Saccharomyces Boulardii (250mg Capsules and Powder Sachets) is a non-pathogenic, tropical probiotic yeast on the WHO Model List framework. It thrives at human body temperature (37°C) and is naturally resistant to antibacterial antibiotics. In the gut lumen, it neutralizes bacterial toxins (Clostridioides difficile toxin A and B, cholera toxin), stimulates mucosal secretory IgA and brush border disaccharidases, and prevents pathogen translocation. Indicated for prevention and treatment of antibiotic-associated diarrhea, C. difficile recurrence, acute infectious rotaviral diarrhea, and enteral nutrition-related diarrhea.

Saccharomyces Boulardii (250mg Capsules and Powder Sachets) is a non-pathogenic, tropical probiotic yeast on the WHO Model List framework. It thrives at human body temperature (37°C) and is naturally resistant to antibacterial antibiotics. In the gut lumen, it neutralizes bacterial toxins (Clostridioides difficile toxin A and B, cholera toxin), stimulates mucosal secretory IgA and brush border disaccharidases, and prevents pathogen translocation. Indicated for prevention and treatment of antibiotic-associated diarrhea, C. difficile recurrence, acute infectious rotaviral diarrhea, and enteral nutrition-related diarrhea.

Racecadotril (100mg Capsules; 10mg, 15mg, 30mg Sachets) is an oral peripheral enkephalinase inhibitor antisecretory antidiarrheal on the WHO Model List framework. It is a prodrug hydrolyzed to thiorphan, which inhibits enkephalinase, sparing endogenous opioid enkephalins in the gut. This selectively reduces intestinal hypersecretion of water and electrolytes induced by cholera toxin, rotavirus, or inflammatory enterotoxins without delaying bowel transit or causing secondary constipation or bacterial overgrowth. Indicated for complementary symptomatic treatment of acute watery diarrhea in adults (capsules) and infants/children >3 months (sachets) alongside Oral Rehydration Therapy (ORS).

Racecadotril (100mg Capsules; 10mg, 15mg, 30mg Sachets) is an oral peripheral enkephalinase inhibitor antisecretory antidiarrheal on the WHO Model List framework. It is a prodrug hydrolyzed to thiorphan, which inhibits enkephalinase, sparing endogenous opioid enkephalins in the gut. This selectively reduces intestinal hypersecretion of water and electrolytes induced by cholera toxin, rotavirus, or inflammatory enterotoxins without delaying bowel transit or causing secondary constipation or bacterial overgrowth. Indicated for complementary symptomatic treatment of acute watery diarrhea in adults (capsules) and infants/children >3 months (sachets) alongside Oral Rehydration Therapy (ORS).

Racecadotril (100mg Capsules; 10mg, 15mg, 30mg Sachets) is an oral peripheral enkephalinase inhibitor antisecretory antidiarrheal on the WHO Model List framework. It is a prodrug hydrolyzed to thiorphan, which inhibits enkephalinase, sparing endogenous opioid enkephalins in the gut. This selectively reduces intestinal hypersecretion of water and electrolytes induced by cholera toxin, rotavirus, or inflammatory enterotoxins without delaying bowel transit or causing secondary constipation or bacterial overgrowth. Indicated for complementary symptomatic treatment of acute watery diarrhea in adults (capsules) and infants/children >3 months (sachets) alongside Oral Rehydration Therapy (ORS).

Mesalazine / Mesalamine (400mg, 500mg, 800mg, 1200mg Delayed Release / Prolonged Release Tablets) is an oral 5-aminosalicylic acid (5-ASA) anti-inflammatory agent on the WHO Model List of Essential Medicines. Formulated with pH-dependent (pH >= 7) enteric coatings or multi-matrix (MMX) core systems to bypass gastric degradation and deliver high local 5-ASA concentrations specifically to the terminal ileum and colon. Locally inhibits 5-lipoxygenase, reduces leukotriene B4 and pro-inflammatory prostaglandin synthesis, and scavenges free radicals without systemic corticosteroid toxicity. Indicated for induction and maintenance of clinical and endoscopic remission in mild-to-moderate ulcerative colitis.

Mesalazine / Mesalamine (400mg, 500mg, 800mg, 1200mg Delayed Release / Prolonged Release Tablets) is an oral 5-aminosalicylic acid (5-ASA) anti-inflammatory agent on the WHO Model List of Essential Medicines. Formulated with pH-dependent (pH >= 7) enteric coatings or multi-matrix (MMX) core systems to bypass gastric degradation and deliver high local 5-ASA concentrations specifically to the terminal ileum and colon. Locally inhibits 5-lipoxygenase, reduces leukotriene B4 and pro-inflammatory prostaglandin synthesis, and scavenges free radicals without systemic corticosteroid toxicity. Indicated for induction and maintenance of clinical and endoscopic remission in mild-to-moderate ulcerative colitis.

Bisacodyl Suppositories (5mg, 10mg) is a rectal stimulant diphenylmethane laxative on the WHO Model List of Essential Medicines. Following rectal insertion, bisacodyl is hydrolyzed by endogenous esterases to active bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM), directly stimulating sensory nerve endings in the colonic and rectal mucosa to initiate vigorous propulsive peristalsis within 15 to 60 minutes. Indicated for acute constipation, evacuation of the colon prior to surgical or radiological procedures, and bowel retraining in neurogenic bowel.

Pre & Pro-Biotic Capsules (Bacillus Mesentericus - 2M + Clostridium Butyricum - 4M + Lactobacillus Sporogenes - 100M + Streptococcus Faecalis - 60M) is an established pharmaceutical agent in the Gastrointestinal & Digestion category on the PMBI National Formulary. Formulated to treat acid peptic disease, digestive dysmotility, or gastrointestinal infection according to verified pharmacopoeial standards.

Mesalazine / Mesalamine (400mg, 500mg, 800mg, 1200mg Delayed Release / Prolonged Release Tablets) is an oral 5-aminosalicylic acid (5-ASA) anti-inflammatory agent on the WHO Model List of Essential Medicines. Formulated with pH-dependent (pH >= 7) enteric coatings or multi-matrix (MMX) core systems to bypass gastric degradation and deliver high local 5-ASA concentrations specifically to the terminal ileum and colon. Locally inhibits 5-lipoxygenase, reduces leukotriene B4 and pro-inflammatory prostaglandin synthesis, and scavenges free radicals without systemic corticosteroid toxicity. Indicated for induction and maintenance of clinical and endoscopic remission in mild-to-moderate ulcerative colitis.

Bisacodyl Suppositories (5mg, 10mg) is a rectal stimulant diphenylmethane laxative on the WHO Model List of Essential Medicines. Following rectal insertion, bisacodyl is hydrolyzed by endogenous esterases to active bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM), directly stimulating sensory nerve endings in the colonic and rectal mucosa to initiate vigorous propulsive peristalsis within 15 to 60 minutes. Indicated for acute constipation, evacuation of the colon prior to surgical or radiological procedures, and bowel retraining in neurogenic bowel.

Nitazoxanide Tablets (500mg) is a synthetic thiazolide broad-spectrum antiprotozoal and antiviral agent. It is rapidly hydrolyzed to its active metabolite tizoxanide, which selectively interferes with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction essential for anaerobic energy metabolism in parasites. Indicated for diarrhea caused by Cryptosporidium parvum, Giardia lamblia, and mixed intestinal parasite infections in immunocompetent patients.