TabletsClinical Overview
Nitazoxanide Tablets (500mg) is a synthetic thiazolide broad-spectrum antiprotozoal and antiviral agent. It is rapidly hydrolyzed to its active metabolite tizoxanide, which selectively interferes with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction essential for anaerobic energy metabolism in parasites. Indicated for diarrhea caused by Cryptosporidium parvum, Giardia lamblia, and mixed intestinal parasite infections in immunocompetent patients.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally 500 mg twice daily with food for 3 consecutive days. Swallow whole with a glass of water. Taking with food significantly enhances bioavailability.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Abdominal pain, diarrhea, nausea, headache, harmless bright yellow discoloration of urine. Rare/Severe: Transaminase elevations, yellow discoloration of sclera, and hypersensitivity.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Take with food. High plasma protein binding (>99%); use with caution in patients taking other highly protein-bound medications with narrow therapeutic indices (warfarin). Efficacy in HIV-associated cryptosporidiosis is limited.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or gastrointestinal treatment recommendations. Always consult a registered gastroenterologist or qualified medical practitioner before initiating, altering, or discontinuing any gastrointestinal medication or digestive therapy.