TabletsClinical Overview
Diphenoxylate Hydrochloride (2.5mg) and Atropine Sulphate (0.025mg) Tablets is a fixed-dose antidiarrheal combination on the WHO Model List framework. Diphenoxylate is a synthetic opioid receptor agonist structurally related to meperidine that slows intestinal motility, prolonging transit time and allowing increased fluid resorption. Subtherapeutic atropine sulphate is included specifically to deter deliberate abuse by causing unpleasant anticholinergic symptoms (dry mouth, tachycardia, flushing) if taken in excessive quantities. Indicated as adjunctive therapy in the management of acute or chronic diarrhea.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Adults: Take orally 2 tablets four times daily (20 mg diphenoxylate daily initial dose) with water. Once diarrhea is controlled, reduce dosage to maintenance level (as low as 1 to 2 tablets daily). Discontinue if no improvement after 10 days.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Drowsiness, dizziness, dry mouth, nausea, abdominal discomfort, constipation. Rare/Severe: Respiratory depression, paralytic ileus, toxic megacolon, atropine toxicity, and physical dependence.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Schedule H Prescription Narcotic Antidiarrheal. Strictly contraindicated in children under 6 years of age due to severe respiratory depression and atropine toxicity risk. Contraindicated in infectious diarrhea, obstructive jaundice, and active ulcerative colitis. Avoid alcohol and sedatives.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or gastrointestinal treatment recommendations. Always consult a registered gastroenterologist or qualified medical practitioner before initiating, altering, or discontinuing any gastrointestinal medication or digestive therapy.
