SolutionClinical Overview
Lactulose Solution (10g/15ml) is a non-absorbable synthetic disaccharide osmotic laxative and ammonia-lowering agent on the WHO Model List of Essential Medicines. In the colon, bacterial flora ferment lactulose into low-molecular-weight organic acids (lactic, acetic, and formic acids), lowering colonic pH. This osmotic effect draws water into the stool, stimulating peristalsis. In hepatic encephalopathy, acidification traps ammonia as non-absorbable ammonium ions (NH4+) and promotes nitrogen excretion by colonic bacteria. Indicated for chronic constipation and prevention/treatment of portal systemic hepatic encephalopathy.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Constipation: Take 15 to 30 mL orally once daily in the morning with a glass of water, milk, or fruit juice. Onset is 24 to 48 hours. Hepatic encephalopathy: Take 30 to 45 mL three to four times daily, titrated to achieve 2 to 3 soft acidic stools per day.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Flatulence, abdominal cramps, meteorism, nausea, diarrhea (with overdose). Rare/Severe: Dehydration, hypernatremia, and hypokalemia with prolonged excessive dosing.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Over-The-Counter laxative. Contraindicated in galactosemia and mechanical bowel obstruction. Diabetics should account for small amounts of free galactose and lactose in the syrup upon chronic high-dose therapy.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or gastrointestinal treatment recommendations. Always consult a registered gastroenterologist or qualified medical practitioner before initiating, altering, or discontinuing any gastrointestinal medication or digestive therapy.