TabletsClinical Overview
Sulfasalazine Gastro-Resistant / Delayed Release Tablets (500mg, 1000mg) is a synthetic azo-bonded conjugate of 5-aminosalicylic acid (5-ASA) and sulfapyridine on the WHO Model List of Essential Medicines. Bacteria in the colon cleave the azo bond via azoreductase enzymes, liberating 5-ASA to exert topical anti-inflammatory action on colonic mucosa, while absorbed sulfapyridine exerts systemic immunomodulatory effects. Indicated for induction and maintenance of remission in ulcerative colitis, active Crohn's disease, and disease-modifying antirheumatic drug (DMARD) therapy for rheumatoid arthritis.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally in evenly divided doses after meals with a full glass of water. Ulcerative colitis flares: 3 to 4 g daily in divided doses; Maintenance: 2 g daily in divided doses. Swallow whole. Maintain high fluid intake (at least 2 liters of water daily) to prevent crystalluria and kidney stone formation.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Nausea, dyspepsia, headache, anorexia, reversible oligospermia, orange-yellow discoloration of urine and skin. Rare/Severe: Severe sulfonamide hypersensitivity (Stevens-Johnson syndrome, DRESS), agranulocytosis, aplastic anemia, hepatic necrosis, and hemolytic anemia (G6PD deficiency).
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Sulfa drug: strictly contraindicated in patients with sulfonamide or salicylate allergy, intestinal/urinary obstruction, and porphyria. Perform complete blood counts and liver function tests every 2 weeks during initial 3 months. Supplement with folic acid (sulfasalazine inhibits folate absorption).
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or gastrointestinal treatment recommendations. Always consult a registered gastroenterologist or qualified medical practitioner before initiating, altering, or discontinuing any gastrointestinal medication or digestive therapy.