Pregnancy, Fertility & Uterine Care

Misoprostol Tablets IP 200 mcg is a synthetic prostaglandin E1 (PGE1) analogue on the WHO Model List of Essential Medicines. It binds to myometrial prostanoid EP receptors, producing strong rhythmic uterine contractions and enzymatic cervical softening/effacement; it also inhibits gastric acid secretion and protects mucosal lining. Indicated for prevention and treatment of postpartum hemorrhage (PPH), cervical ripening and labor induction, medical termination of pregnancy (in combination with mifepristone), and prevention of NSAID-induced peptic ulcers.

Clomiphene Citrate Tablets IP 50 mg is a non-steroidal selective estrogen receptor modulator (SERM) and first-line ovulatory stimulant on the WHO Model List of Essential Medicines. It antagonizes hypothalamic and pituitary estrogen receptors, blocking negative feedback of endogenous circulating estrogens; this triggers an increase in GnRH pulse frequency and endogenous FSH and LH secretion, stimulating ovarian follicular recruitment and maturation. Indicated for the treatment of ovulatory failure and female anovulatory infertility in women desiring pregnancy, predominantly in polycystic ovary syndrome (PCOS, WHO Group II anovulation).

Doxylamine Succinate and Pyridoxine Hydrochloride Tablets (10mg/10mg, 20mg/20mg) is the first-line evidence-based pharmacotherapy recommended by ACOG and RCOG for nausea and vomiting of pregnancy (NVP / morning sickness) and hyperemesis gravidarum. Doxylamine is an ethanolamine-derivative H1-antihistamine that competitively blocks H1 and muscarinic receptors in the vestibular system and vomiting center; Pyridoxine (Vitamin B6) acts as a coenzyme in neurotransmitter synthesis, improving metabolic pathways disrupted during early pregnancy.

Combipack of Mifepristone 200mg (1 Tablet) & Misoprostol 200mcg (4 Tablets) is a sequential antiprogestogenic and prostaglandin regimen approved under the Medical Termination of Pregnancy (MTP) Act for the medical termination of intrauterine pregnancy up to 63 days (9 weeks) of gestation. Mifepristone blocks uterine progesterone receptors, terminating fetal viability and sensitizing the myometrium, followed by Misoprostol which stimulates strong myometrial contractions and cervical dilation to expel gestational products.

Dehydroepiandrosterone (Micronized) 25 mg Capsule is an endogenous steroid prohormone synthesized by the adrenal cortex and ovarian theca cells. As a metabolic precursor to androstenedione, testosterone, and estrone, it plays a critical role in follicular steroidogenesis, enhancing preantral and antral follicle sensitivity to FSH via IGF-1 mediation. Indicated as an adjuvant reproductive therapy for diminished ovarian reserve (DOR), poor ovarian response (POR) in IVF cycles, advanced maternal reproductive age, and age-related hormonal insufficiency.

Cabergoline Tablets IP 0.5 mg is a potent, long-acting synthetic ergoline dopamine D2-receptor agonist on the WHO Model List of Essential Medicines. By directly stimulating D2 receptors on anterior pituitary lactotroph cells, it potently suppresses prolactin secretion with a biological half-life of 63 to 69 hours. Indicated for the treatment of hyperprolactinemia (due to idiopathic causes, prolactin-secreting pituitary adenomas/prolactinomas, or empty sella syndrome), inhibition/suppression of physiological postpartum lactation, and prevention of ovarian hyperstimulation syndrome (OHSS) in ART cycles.

Human Chorionic Gonadotrophin (hCG) IP 5000 IU (Powder for injection with solvent) is a purified polypeptide gonadotropic hormone obtained from the urine of pregnant women. It acts as an LH surrogate by binding to the LH/CG receptor on granulosa and theca cells, triggering final oocyte maturation, follicular rupture (ovulation), and luteinization of the ruptured follicle with sustained progesterone production. Indicated for ovulation induction and luteal phase support in anovulatory infertility/assisted reproduction (IVF/IUI), and for prepubertal cryptorchidism and hypogonadotropic hypogonadism in males.

Doxylamine Succinate and Pyridoxine Hydrochloride Tablets (10mg/10mg, 20mg/20mg) is the first-line evidence-based pharmacotherapy recommended by ACOG and RCOG for nausea and vomiting of pregnancy (NVP / morning sickness) and hyperemesis gravidarum. Doxylamine is an ethanolamine-derivative H1-antihistamine that competitively blocks H1 and muscarinic receptors in the vestibular system and vomiting center; Pyridoxine (Vitamin B6) acts as a coenzyme in neurotransmitter synthesis, improving metabolic pathways disrupted during early pregnancy.

Allylestrenol Tablets 5 mg is a synthetic oral progestogen derivative of 19-nortestosterone designed specifically for obstetric support. It stimulates placental trophoblast activity, enhances endogenous placental progesterone and human chorionic gonadotrophin (hCG) synthesis, normalizes oxytocinase levels, and suppresses myometrial hypercontractility without exerting androgenic or estrogenic virilizing effects on the female fetus. Indicated for threatened miscarriage, habitual abortion, threatened preterm labor, and intrauterine growth restriction (IUGR) due to placental insufficiency.

Isoxsuprine Injection IP 5 mg is a beta-2 adrenergic receptor agonist and direct vascular/uterine smooth muscle relaxant. By stimulating beta-2 adrenoreceptors in the myometrium, it activates adenylate cyclase and increases intracellular cAMP, decreasing intracellular calcium and producing profound relaxation of uterine smooth muscle (tocolysis); it also produces peripheral vasodilation. Indicated for the management of threatened abortion, threatened uncomplicated premature labor (tocolytic therapy between 20-36 weeks gestation), and peripheral vascular diseases (Raynaud's phenomenon, arteriosclerosis obliterans).

Valethamate Bromide Injection 8 mg/ml is a synthetic anticholinergic quaternary ammonium compound with combined antimuscarinic and direct musculotropic antispasmodic properties. It selectively blocks muscarinic receptors on the cervix and lowers cervical smooth muscle tone, facilitating rapid cervical softening, effacement, and dilatation without impairing physiological fundal myometrial contractions. Indicated for acceleration of cervical dilatation in the active phase of labor, management of cervical dystocia, and visceral spasms (spasmodic dysmenorrhea, biliary/renal colic).

Anti-D (Rho) Immunoglobulin (Monoclonal) 300 mcg is a sterile preparation of specific human IgG antibodies against the Rh(D) antigen on red blood cells, produced using recombinant or human monoclonal technology, on the WHO Model List of Essential Medicines. It binds to and neutralizes circulating fetal Rh(D)-positive erythrocytes in the maternal bloodstream before maternal immune recognition occurs, preventing maternal B-cell sensitization and Rh isoimmunization. Indicated for the prevention of hemolytic disease of the newborn (HDN) in Rh-negative mothers pregnant with an Rh-positive infant, routine antenatal prophylaxis at 28 weeks gestation, postpartum administration within 72 hours of delivery, and following miscarriages, ectopic pregnancies, amniocentesis, or abdominal trauma.

Carboprost Tromethamine Injection 125 mcg is a synthetic 15-methyl analogue of Prostaglandin F2-alpha (PGF2a). It produces sustained, intense myometrial contractions and local vasoconstriction to achieve mechanical hemostasis at the placental bed. Indicated for the control and refractory treatment of severe postpartum hemorrhage (PPH) due to uterine atony that has failed to respond to oxytocin, methylergometrine, or uterine massage, and for mid-trimester abortion.

Dinoprostone Gel 0.5 mg (Pre-filled syringe) is a sterile endocervical gel containing synthetic Prostaglandin E2 (PGE2) on the WHO Model List of Essential Medicines. It stimulates local collagenase breakdown, cervical ripening, dilatation, and myometrial contractility mimicking natural onset of labor. Indicated for cervical ripening and induction of labor in pregnant women at or near term with a medical or obstetric indication for induction and an unfavorable Bishop's score (<=6).

Hydroxyprogesterone Caproate Injection IP (250mg, 500mg) is a long-acting synthetic esterified progestogen formulated in an oily depot solution. It binds to uterine progesterone receptors, producing prolonged quietening of the myometrium, inhibiting cervical shortening, and suppressing inflammatory cytokine-mediated uterine contractility. Indicated for the prevention of recurrent preterm birth in pregnant women with a singleton pregnancy and a documented history of spontaneous preterm singleton delivery, habitual/threatened miscarriage, and uterine bleeding disorders.

Hydroxyprogesterone Caproate Injection IP (250mg, 500mg) is a long-acting synthetic esterified progestogen formulated in an oily depot solution. It binds to uterine progesterone receptors, producing prolonged quietening of the myometrium, inhibiting cervical shortening, and suppressing inflammatory cytokine-mediated uterine contractility. Indicated for the prevention of recurrent preterm birth in pregnant women with a singleton pregnancy and a documented history of spontaneous preterm singleton delivery, habitual/threatened miscarriage, and uterine bleeding disorders.

Carbetocin Injection 100 mcg/ml is a synthetic, long-acting nonapeptide analogue of human oxytocin on the WHO Model List of Essential Medicines. It possesses structural modifications that provide resistance to enzymatic degradation, conferring a half-life of ~40 minutes (4 to 10 times longer than oxytocin) and generating continuous rhythmic uterine contractions for several hours. Indicated for the prevention of postpartum hemorrhage (PPH) due to uterine atony following vaginal birth or cesarean delivery under epidural or spinal anesthesia.