TabletsClinical Overview
Doxylamine Succinate and Pyridoxine Hydrochloride Tablets (10mg/10mg, 20mg/20mg) is the first-line evidence-based pharmacotherapy recommended by ACOG and RCOG for nausea and vomiting of pregnancy (NVP / morning sickness) and hyperemesis gravidarum. Doxylamine is an ethanolamine-derivative H1-antihistamine that competitively blocks H1 and muscarinic receptors in the vestibular system and vomiting center; Pyridoxine (Vitamin B6) acts as a coenzyme in neurotransmitter synthesis, improving metabolic pathways disrupted during early pregnancy.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally on an empty stomach with a glass of water: Standard regimen is 2 tablets at bedtime (or one 20mg/20mg tablet at bedtime) to control morning symptoms. If symptoms persist into the afternoon/evening, escalate to 1 tablet in the morning, 1 in the mid-afternoon, and 2 at bedtime (maximum 40 mg doxylamine / 40 mg pyridoxine daily). Swallow whole; do NOT crush, chew, or split delayed-release tablets.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Somnolence / daytime drowsiness, dry mouth, dizziness, headache, fatigue, nervousness, and mild constipation. Rare/Severe: Severe sedation, urinary retention, blurred vision, and hypersensitivity reactions.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Category A safety profile in pregnancy established across extensive epidemiological studies. Avoid alcohol and other CNS depressants due to additive sedation. Caution when driving or operating machinery. Contraindicated in patients with asthma, narrow-angle glaucoma, and concurrent MAO inhibitors.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Gynecological, Obstetric & Endocrinological Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice or reproductive healthcare guidance. Hormonal medications, uterotonics, corticosteroids, fertility therapies, and emergency contraceptives have profound systemic actions and must be administered strictly under the supervision of a registered gynecologist, obstetrician, or endocrinologist.
Pyridoxine Hydrochloride 10mg, Doxylamine 10mg and Folic Acid 2.5mg Tablets
Folic Acid (5mg, 15mg) and L-Methylfolate Calcium (1mg, 2.8mg, 7.5mg Tablets) is an essential water-soluble B-vitamin and active tetrahydrofolate derivative on the WHO Model List of Essential Medicines. L-Methylfolate is the active methylated metabolite (5-MTHF) that crosses the blood-brain barrier directly without requiring enzymatic reduction by methylenetetrahydrofolate reductase (MTHFR). Transports one-carbon units for purine and thymidylate synthesis, essential for DNA replication, cell division, and homocysteine remethylation. Indicated for prevention of neural tube defects (spina bifida, anencephaly) in pregnancy, treatment of folate deficiency megaloblastic anemia, hyperhomocysteinemia, and adjunctive therapy in depression.
Vitamin B-Complex Tablets (B1, B2, B3, B5, B6, B12)
Thiamine Hydrochloride Tablets (100mg) is an oral Vitamin B1 preparation on the WHO Model List of Essential Medicines for prevention and treatment of thiamine deficiency, dry and wet beriberi, and nutritional support in chronic alcoholism.
Vitamin B-Complex Syrup
Thiamine Hydrochloride Tablets (100mg) is an oral Vitamin B1 preparation on the WHO Model List of Essential Medicines for prevention and treatment of thiamine deficiency, dry and wet beriberi, and nutritional support in chronic alcoholism.
Thiamine, Pyridoxine & Cyanocobalamin Injection (3ml)
Thiamine Hydrochloride (100mg), Pyridoxine Hydrochloride (100mg) and Cyanocobalamin (1000mcg) per 3ml Injection is a parenteral neurotropic B-vitamin formulation used for acute neuropathies, severe nutritional deficiency, and Wernicke-Korsakoff syndrome.