InjectionClinical Overview
Valethamate Bromide Injection 8 mg/ml is a synthetic anticholinergic quaternary ammonium compound with combined antimuscarinic and direct musculotropic antispasmodic properties. It selectively blocks muscarinic receptors on the cervix and lowers cervical smooth muscle tone, facilitating rapid cervical softening, effacement, and dilatation without impairing physiological fundal myometrial contractions. Indicated for acceleration of cervical dilatation in the active phase of labor, management of cervical dystocia, and visceral spasms (spasmodic dysmenorrhea, biliary/renal colic).
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
For Intramuscular (IM) or Slow Intravenous (IV) administration ONLY by a qualified obstetrician in a labor room setting: 8 mg (1 ampoule) IM or slow IV administered when the cervix is dilated >=3-4 cm with regular rhythmic contractions. May be repeated at intervals of 30 to 45 minutes up to a maximum of 3 doses (24 mg total). Continuous monitoring of maternal heart rate, fetal heart rate, and uterine activity is required.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Dry mouth, transient tachycardia, flushing of skin, blurred vision, dizziness, thirst, and nausea. Rare/Severe: Marked maternal tachycardia (>140 bpm), severe urinary retention, paralytic ileus, and acute angle-closure glaucoma.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Contraindicated in glaucoma, obstructive uropathy, intestinal obstruction, severe cardiac tachyarrhythmias, myasthenia gravis, and non-reassuring fetal status. Ensure adequate maternal hydration.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Gynecological, Obstetric & Endocrinological Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice or reproductive healthcare guidance. Hormonal medications, uterotonics, corticosteroids, fertility therapies, and emergency contraceptives have profound systemic actions and must be administered strictly under the supervision of a registered gynecologist, obstetrician, or endocrinologist.