Anaesthetics & Local Numbing

Bupivacaine Hydrochloride is a long-acting amino-amide local and regional anesthetic on the WHO Model List of Essential Medicines. It blocks the generation and conduction of nerve impulses by reversibly binding and inhibiting voltage-gated sodium channels in the neuronal cell membrane. Features high lipid solubility and a prolonged duration of action (up to 3-6 hours). Indicated for spinal anesthesia, epidural block, peripheral nerve blocks, and post-operative infiltration analgesia.

Lignocaine (Lidocaine) Hydrochloride is the gold-standard amino-amide local anesthetic and Class Ib antiarrhythmic agent on the WHO Model List of Essential Medicines. It reversibly blocks voltage-gated sodium channels in neuronal cell membranes, stopping the generation and propagation of pain signals. When combined with Adrenaline (Epinephrine 1:80,000), localized vasoconstriction reduces surgical bleeding, slows systemic anesthetic absorption, and doubles the duration of local anesthesia. Indicated for infiltration anesthesia, regional nerve blocks, epidural anesthesia, and treatment of acute ventricular arrhythmias.

Lignocaine (Lidocaine) Hydrochloride is the gold-standard amino-amide local anesthetic and Class Ib antiarrhythmic agent on the WHO Model List of Essential Medicines. It reversibly blocks voltage-gated sodium channels in neuronal cell membranes, stopping the generation and propagation of pain signals. When combined with Adrenaline (Epinephrine 1:80,000), localized vasoconstriction reduces surgical bleeding, slows systemic anesthetic absorption, and doubles the duration of local anesthesia. Indicated for infiltration anesthesia, regional nerve blocks, epidural anesthesia, and treatment of acute ventricular arrhythmias.

Propofol is an ultra-short-acting alkylphenol intravenous general anesthetic on the WHO Model List of Essential Medicines. It acts by positive allosteric modulation of GABAA receptors, slowing channel closing time and potentiating GABA-mediated inhibitory synaptic currents, while inhibiting NMDA receptors. Features exceptionally rapid onset (around 30 seconds) and fast recovery without residual "hangover." Indicated for induction and maintenance of general anesthesia, sedation for surgical/diagnostic procedures, and sedation of mechanically ventilated ICU adults.

Atracurium Besylate is an intermediate-acting non-depolarizing neuromuscular blocking agent on the WHO Model List of Essential Medicines. It competitively antagonizes nicotinic acetylcholine receptors at the motor endplate of skeletal muscles. It undergoes unique spontaneous non-enzymatic degradation at physiological pH and temperature (Hofmann elimination) and ester hydrolysis, making its duration of action independent of hepatic or renal function. Indicated as an adjunct to general anesthesia to facilitate endotracheal intubation and skeletal muscle relaxation during surgery or mechanical ventilation in intensive care.

Lignocaine (Lidocaine) Hydrochloride Gel 2% w/v is an evidence-based dermatological formulation. It acts by delivering targeted active therapeutic ingredients to cutaneous lesions to relieve skin pathology, restore barrier integrity, and manage dermatoses.

Vecuronium Bromide is an intermediate-acting monoquaternary aminosteroid non-depolarizing neuromuscular blocking agent on the WHO Model List of Essential Medicines. It competitively blocks acetylcholine at motor endplate nicotinic receptors. Unlike atracurium or tubocurarine, it does not induce histamine release or autonomic ganglion blockade, conferring exceptional cardiovascular stability without tachycardia or hypotension. Indicated for skeletal muscle relaxation during surgical procedures and mechanical ventilation.

Lignocaine (Lidocaine) Hydrochloride is the gold-standard amino-amide local anesthetic and Class Ib antiarrhythmic agent on the WHO Model List of Essential Medicines. It reversibly blocks voltage-gated sodium channels in neuronal cell membranes, stopping the generation and propagation of pain signals. When combined with Adrenaline (Epinephrine 1:80,000), localized vasoconstriction reduces surgical bleeding, slows systemic anesthetic absorption, and doubles the duration of local anesthesia. Indicated for infiltration anesthesia, regional nerve blocks, epidural anesthesia, and treatment of acute ventricular arrhythmias.

Gabapentin, Lignocaine (Lidocaine), and Baclofen topical gel is a localized multi-modal compound for refractory neuropathic and musculoskeletal pain. Gabapentin provides regional neuro-inhibition via calcium channel modulation; lignocaine reversibly blocks neuronal sodium channels to arrest pain impulse conduction; and baclofen activates GABAB receptors, inducing local skeletal muscle relaxation and mitigating spastic myofascial trigger points. Indicated for localized post-herpetic neuralgia, superficial neuropathic pain, and focal myofascial pain syndromes.

Lignocaine (Lidocaine) and Nifedipine topical cream is a specialized anorectal formulation. Lignocaine reversibly blocks neuronal sodium channels to provide rapid local analgesia, relieving severe anal pain and spasm, while nifedipine, a calcium channel blocker, relaxes the hypertonic internal anal sphincter muscle, reducing resting anal pressure and enhancing local mucosal blood perfusion to promote tissue healing. Indicated for the conservative medical management of acute and chronic anal fissures.

Lignocaine 2.5% & Prilocaine 2.5% Topical Gel (EMLA) is an evidence-based dermatological formulation. It acts by delivering targeted active therapeutic ingredients to cutaneous lesions to relieve skin pathology, restore barrier integrity, and manage dermatoses.