InjectionClinical Overview
Atracurium Besylate is an intermediate-acting non-depolarizing neuromuscular blocking agent on the WHO Model List of Essential Medicines. It competitively antagonizes nicotinic acetylcholine receptors at the motor endplate of skeletal muscles. It undergoes unique spontaneous non-enzymatic degradation at physiological pH and temperature (Hofmann elimination) and ester hydrolysis, making its duration of action independent of hepatic or renal function. Indicated as an adjunct to general anesthesia to facilitate endotracheal intubation and skeletal muscle relaxation during surgery or mechanical ventilation in intensive care.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Administered strictly by certified anesthesiologists via intravenous injection or continuous IV infusion with continuous neuromuscular transmission monitoring (train-of-four). Must only be administered when facilities for immediate endotracheal intubation, artificial respiration, and reversal agents (neostigmine) are available.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Transient skin flushing, mild hypotension, tachycardia, histamine-mediated erythema. Rare/Severe: Severe bronchospasm, profound anaphylactoid reactions, and prolonged neuromuscular paralysis.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Black box warning: Causes respiratory arrest through skeletal muscle paralysis; must only be given with artificial ventilation. Laudanosine metabolite may accumulate during prolonged ICU infusion, potentially lowering seizure threshold.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified pharmacist before initiating, modifying, or substituting any medication regimen.