InjectionClinical Overview
Bupivacaine Hydrochloride is a long-acting amino-amide local and regional anesthetic on the WHO Model List of Essential Medicines. It blocks the generation and conduction of nerve impulses by reversibly binding and inhibiting voltage-gated sodium channels in the neuronal cell membrane. Features high lipid solubility and a prolonged duration of action (up to 3-6 hours). Indicated for spinal anesthesia, epidural block, peripheral nerve blocks, and post-operative infiltration analgesia.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Administered strictly by experienced anesthesiologists or surgeons via local infiltration, epidural, or intrathecal (spinal) injection. Aspiration for blood or cerebrospinal fluid must always be performed prior to injection to avoid accidental intravascular administration. 20% lipid emulsion (Intralipid) must be immediately accessible for rescue.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Hypotension, bradycardia, urinary retention, nausea, numbness/paresthesia. Rare/Severe: Black box warning: Accidental intravascular injection causes severe cardiotoxicity (refractory ventricular arrhythmias, electromechanical dissociation, cardiac arrest resistant to standard defibrillation), neurotoxicity, and high spinal block.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Black box warning for cardiotoxicity: Accidental systemic IV injection causes intractable cardiovascular collapse; 0.75% bupivacaine is strictly contraindicated for obstetrical epidural anesthesia. Lipid emulsion resuscitation protocol must be available.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified pharmacist before initiating, modifying, or substituting any medication regimen.