Muscle Relaxants & Spasm Care

Paracetamol (325mg/500mg) and Chlorzoxazone (250mg) Tablets is a centrally acting skeletal muscle relaxant and analgesic combination. Chlorzoxazone inhibits multi-synaptic reflex arcs in the spinal cord and subcortical areas of the brain, relieving painful skeletal muscle spasms. Paracetamol acts centrally to alleviate associated pain and discomfort. Indicated for acute, painful musculoskeletal conditions, muscle spasms, lumbago, torticollis, and strain/sprain trauma.

Aceclofenac (100mg) and Thiocolchicoside (4mg/8mg, with or without Paracetamol 325mg) Tablets is a potent muscle relaxant and anti-inflammatory combination. Aceclofenac inhibits COX-2-mediated prostaglandin synthesis, reducing joint and tissue inflammation. Thiocolchicoside is a semi-synthetic sulfur derivative of colchicoside that acts as a competitive antagonist at GABA-A and glycine receptors, exerting central muscle relaxant action to eliminate painful muscle contractures without causing heavy sedative drowsiness. Indicated for acute painful musculoskeletal conditions, acute lumbago, cervical radiculopathy, sprains, spasms, and post-traumatic muscle contractures.

Baclofen Tablets (10mg, 20mg Extended Release Gastric Retentive System) is an oral centrally acting skeletal muscle relaxant and antispasticity agent on the WHO Model List of Essential Medicines. It is a synthetic chemical analogue of gamma-aminobutyric acid (GABA) that selectively activates G-protein-coupled presynaptic GABA-B receptors in the spinal cord. This stimulates hyperpolarization by increasing potassium conductance and inhibits calcium influx, reducing the release of excitatory neurotransmitters (glutamate, aspartate) and dampening mono- and polysynaptic spinal reflexes. Indicated for alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, spinal cord trauma, transverse myelitis, and motor neuron disease.

Paracetamol (325mg/500mg) and Chlorzoxazone (250mg) Tablets is a centrally acting skeletal muscle relaxant and analgesic combination. Chlorzoxazone inhibits multi-synaptic reflex arcs in the spinal cord and subcortical areas of the brain, relieving painful skeletal muscle spasms. Paracetamol acts centrally to alleviate associated pain and discomfort. Indicated for acute, painful musculoskeletal conditions, muscle spasms, lumbago, torticollis, and strain/sprain trauma.

Paracetamol (325mg/500mg) and Chlorzoxazone (250mg) Tablets is a centrally acting skeletal muscle relaxant and analgesic combination. Chlorzoxazone inhibits multi-synaptic reflex arcs in the spinal cord and subcortical areas of the brain, relieving painful skeletal muscle spasms. Paracetamol acts centrally to alleviate associated pain and discomfort. Indicated for acute, painful musculoskeletal conditions, muscle spasms, lumbago, torticollis, and strain/sprain trauma.

Tizanidine Tablets (2mg) is an oral centrally acting imidazoline-derivative alpha-2 adrenergic receptor agonist on the WHO Model List framework. It binds to presynaptic alpha-2 adrenergic receptors in the spinal cord, reducing facilitation of spinal motor neurons and suppressing polysynaptic reflexes, relieving muscle hypertonia and spasms without causing significant muscle weakness. Indicated for painful muscle spasms associated with spinal disorders, torticollis, lumbago, and spasticity in multiple sclerosis or spinal cord injury.

Drotaverine Hydrochloride (80mg) and Aceclofenac (100mg) Tablets combines a selective phosphodiesterase-4 (PDE4) inhibitor smooth muscle relaxant with a COX-2 preferential NSAID. Drotaverine elevates cyclic AMP in visceral smooth muscle to abolish spastic contractions, while aceclofenac inhibits prostaglandin synthesis, eliminating inflammation and pain. Indicated for severe spasmodic dysmenorrhea, biliary colic, renal/ureteric colic, and spasmodic abdominal pain.

Thiocolchicoside Capsules (4mg) is a semi-synthetic sulfurated glucoside derivative of colchicine functioning as a central muscle relaxant on the PMBI formulary. It acts as a selective competitive antagonist at GABA-A and glycine receptors in the central nervous system, relieving painful reflex muscle contractures, hypertonia, and myofascial spasms without inducing sedative impairment or muscular paresis. Indicated for adjuvant treatment of painful acute muscle contractures in acute spinal pathologies (acute lumbago, torticollis, sprains).

Paracetamol / Acetaminophen (Tablets 500mg, 650mg, 1000mg; Oral Suspension 120mg, 125mg, 250mg per 5ml; Drops 100mg/ml) is a first-line non-opioid analgesic and antipyretic on the WHO Model List of Essential Medicines. It selectively inhibits central prostaglandin synthesis through peroxidase-dependent inhibition of COX enzymes in the brain and spinal cord, activates descending serotonergic inhibitory pathways, and resets the hypothalamic thermoregulatory center to reduce fever through cutaneous vasodilation and sweating. Unlike NSAIDs, it does NOT inhibit peripheral cyclooxygenase, causing zero gastric mucosal ulceration, platelet dysfunction, or renal vasoconstriction. Indicated as first-line therapy for mild-to-moderate pain (headache, toothache, dysmenorrhea, osteoarthritis) and fever of diverse etiologies.

Paracetamol / Acetaminophen (Tablets 500mg, 650mg, 1000mg; Oral Suspension 120mg, 125mg, 250mg per 5ml; Drops 100mg/ml) is a first-line non-opioid analgesic and antipyretic on the WHO Model List of Essential Medicines. It selectively inhibits central prostaglandin synthesis through peroxidase-dependent inhibition of COX enzymes in the brain and spinal cord, activates descending serotonergic inhibitory pathways, and resets the hypothalamic thermoregulatory center to reduce fever through cutaneous vasodilation and sweating. Unlike NSAIDs, it does NOT inhibit peripheral cyclooxygenase, causing zero gastric mucosal ulceration, platelet dysfunction, or renal vasoconstriction. Indicated as first-line therapy for mild-to-moderate pain (headache, toothache, dysmenorrhea, osteoarthritis) and fever of diverse etiologies.

Etoricoxib (60mg) and Thiocolchicoside (4mg) Tablets combines a highly selective COX-2 inhibitor with a non-sedating muscle relaxant. Etoricoxib blocks inflammatory prostaglandins with >100-fold selectivity over COX-1, causing significantly less gastrointestinal ulceration than non-selective NSAIDs, while thiocolchicoside eliminates painful muscle spasms via central GABA-A/glycine receptor antagonism. Indicated for acute low back pain, acute torticollis, cervical radiculopathy, and severe muscular spasms associated with spinal osteoarthritis.

Paracetamol (325mg/500mg) and Chlorzoxazone (250mg) Tablets is a centrally acting skeletal muscle relaxant and analgesic combination. Chlorzoxazone inhibits multi-synaptic reflex arcs in the spinal cord and subcortical areas of the brain, relieving painful skeletal muscle spasms. Paracetamol acts centrally to alleviate associated pain and discomfort. Indicated for acute, painful musculoskeletal conditions, muscle spasms, lumbago, torticollis, and strain/sprain trauma.

Baclofen Tablets (10mg, 20mg Extended Release Gastric Retentive System) is an oral centrally acting skeletal muscle relaxant and antispasticity agent on the WHO Model List of Essential Medicines. It is a synthetic chemical analogue of gamma-aminobutyric acid (GABA) that selectively activates G-protein-coupled presynaptic GABA-B receptors in the spinal cord. This stimulates hyperpolarization by increasing potassium conductance and inhibits calcium influx, reducing the release of excitatory neurotransmitters (glutamate, aspartate) and dampening mono- and polysynaptic spinal reflexes. Indicated for alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, spinal cord trauma, transverse myelitis, and motor neuron disease.

Aceclofenac (100mg, with or without Paracetamol 325mg) and Tizanidine (2mg) Tablets combines an NSAID with a centrally acting alpha-2 adrenergic receptor agonist muscle relaxant. Tizanidine stimulates presynaptic alpha-2 receptors in the spinal cord, inhibiting excitatory amino acid (glutamate/aspartate) release from interneurons to reduce spasticity and muscle tone. Indicated for painful muscle spasms associated with static and functional spine disorders (cervical and lumbar syndromes) and acute musculoskeletal trauma.

Diclofenac Sodium (50mg) and Thiocolchicoside (4mg/8mg) Tablets combines a potent NSAID with a central non-sedating muscle relaxant. Relieves pain, inflammation, and muscle contracture in acute lumbago, torticollis, sprains, and spinal radiculopathies.

Diclofenac Sodium (50mg) and Thiocolchicoside (4mg/8mg) Tablets combines a potent NSAID with a central non-sedating muscle relaxant. Relieves pain, inflammation, and muscle contracture in acute lumbago, torticollis, sprains, and spinal radiculopathies.

Diclofenac Sodium/Potassium Tablets (50mg Gastro-Resistant, 75mg/100mg Prolonged Release) is an oral phenylacetic acid non-steroidal anti-inflammatory drug (NSAID) on the WHO Model List of Essential Medicines. It potently inhibits both cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes, halting prostaglandin synthesis, and also reduces intracellular concentrations of free arachidonic acid in leukocytes. Potassium salt provides rapid dissolution and quick pain relief; sodium prolonged-release provides steady 24-hour therapeutic coverage. Indicated for relief of pain and inflammation in osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute musculoskeletal disorders, and acute migraine attacks.