TabletsClinical Overview
Baclofen Tablets (10mg, 20mg Extended Release Gastric Retentive System) is an oral centrally acting skeletal muscle relaxant and antispasticity agent on the WHO Model List of Essential Medicines. It is a synthetic chemical analogue of gamma-aminobutyric acid (GABA) that selectively activates G-protein-coupled presynaptic GABA-B receptors in the spinal cord. This stimulates hyperpolarization by increasing potassium conductance and inhibits calcium influx, reducing the release of excitatory neurotransmitters (glutamate, aspartate) and dampening mono- and polysynaptic spinal reflexes. Indicated for alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, spinal cord trauma, transverse myelitis, and motor neuron disease.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally with food or milk with a full glass of water. Start at 5 mg three times daily; gradually titrate upward every 3 days by 5 mg per dose up to 40 mg to 80 mg daily in divided doses. Swallow extended-release tablets whole. NEVER discontinue abruptly.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Somnolence, sedation, dizziness, muscular weakness, fatigue, nausea, confusion, headache. Rare/Severe: Severe withdrawal syndrome upon abrupt cessation (auditory/visual hallucinations, delirium, hyperthermia, seizures, and rebound spasticity), respiratory depression, and coma.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Black Box Warning: Abrupt discontinuation can precipitate life-threatening withdrawal syndrome (hyperpyrexia, seizures, psychotic delirium, rhabdomyolysis, and death); always taper dose gradually over 1 to 2 weeks. Causes marked somnolence; avoid driving or operating machinery. Strictly avoid alcohol. Dose must be reduced in renal impairment.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or analgesic treatment guidance. Always consult a registered physician or orthopedic specialist before taking pain relievers, anti-inflammatory medications, or anti-arthritic therapies.
Baclofen Tablets 10 mg
Baclofen Tablets (10mg, 20mg Extended Release Gastric Retentive System) is an oral centrally acting skeletal muscle relaxant and antispasticity agent on the WHO Model List of Essential Medicines. It is a synthetic chemical analogue of gamma-aminobutyric acid (GABA) that selectively activates G-protein-coupled presynaptic GABA-B receptors in the spinal cord. This stimulates hyperpolarization by increasing potassium conductance and inhibits calcium influx, reducing the release of excitatory neurotransmitters (glutamate, aspartate) and dampening mono- and polysynaptic spinal reflexes. Indicated for alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, spinal cord trauma, transverse myelitis, and motor neuron disease.
Gabapentin 6% w/w + Lignocaine 5% w/w + Baclofen 2% w/w gel
Gabapentin, Lignocaine (Lidocaine), and Baclofen topical gel is a localized multi-modal compound for refractory neuropathic and musculoskeletal pain. Gabapentin provides regional neuro-inhibition via calcium channel modulation; lignocaine reversibly blocks neuronal sodium channels to arrest pain impulse conduction; and baclofen activates GABAB receptors, inducing local skeletal muscle relaxation and mitigating spastic myofascial trigger points. Indicated for localized post-herpetic neuralgia, superficial neuropathic pain, and focal myofascial pain syndromes.