Clinical Overview
Tizanidine Tablets (2mg) is an oral centrally acting imidazoline-derivative alpha-2 adrenergic receptor agonist on the WHO Model List framework. It binds to presynaptic alpha-2 adrenergic receptors in the spinal cord, reducing facilitation of spinal motor neurons and suppressing polysynaptic reflexes, relieving muscle hypertonia and spasms without causing significant muscle weakness. Indicated for painful muscle spasms associated with spinal disorders, torticollis, lumbago, and spasticity in multiple sclerosis or spinal cord injury.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally starting with 2 mg up to three times daily with water, with or without food. Can be titrated up to 4 mg to 8 mg per dose (maximum 24-36 mg daily). Be consistent with food timing (food increases bioavailability).
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Somnolence, dry mouth, dizziness, fatigue, asthenia, hypotension, bradycardia. Rare/Severe: Severe hypotension, syncope, QT prolongation, and drug-induced hepatotoxicity (transaminase elevations in ~5%).
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Black Box Contraindication: Strictly contraindicated with potent CYP1A2 inhibitors (fluvoxamine, ciprofloxacin) due to massive increases in tizanidine plasma concentrations causing profound hypotension, bradycardia, and coma. Monitor liver enzymes at baseline, 1, 3, and 6 months. Causes marked sedation; do not drive.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or analgesic treatment guidance. Always consult a registered physician or orthopedic specialist before taking pain relievers, anti-inflammatory medications, or anti-arthritic therapies.
Aceclofenac 100mg + Paracetamol 325mg + Tizanidine 2mg Tablets
Paracetamol / Acetaminophen (Tablets 500mg, 650mg, 1000mg; Oral Suspension 120mg, 125mg, 250mg per 5ml; Drops 100mg/ml) is a first-line non-opioid analgesic and antipyretic on the WHO Model List of Essential Medicines. It selectively inhibits central prostaglandin synthesis through peroxidase-dependent inhibition of COX enzymes in the brain and spinal cord, activates descending serotonergic inhibitory pathways, and resets the hypothalamic thermoregulatory center to reduce fever through cutaneous vasodilation and sweating. Unlike NSAIDs, it does NOT inhibit peripheral cyclooxygenase, causing zero gastric mucosal ulceration, platelet dysfunction, or renal vasoconstriction. Indicated as first-line therapy for mild-to-moderate pain (headache, toothache, dysmenorrhea, osteoarthritis) and fever of diverse etiologies.
Aceclofenac 100mg + Tizanidine 2mg Tablets
Aceclofenac (100mg, with or without Paracetamol 325mg) and Tizanidine (2mg) Tablets combines an NSAID with a centrally acting alpha-2 adrenergic receptor agonist muscle relaxant. Tizanidine stimulates presynaptic alpha-2 receptors in the spinal cord, inhibiting excitatory amino acid (glutamate/aspartate) release from interneurons to reduce spasticity and muscle tone. Indicated for painful muscle spasms associated with static and functional spine disorders (cervical and lumbar syndromes) and acute musculoskeletal trauma.