Supplements – relevant products and ingredient information

Folic Acid (5mg, 15mg) and L-Methylfolate Calcium (1mg, 2.8mg, 7.5mg Tablets) is an essential water-soluble B-vitamin and active tetrahydrofolate derivative on the WHO Model List of Essential Medicines. L-Methylfolate is the active methylated metabolite (5-MTHF) that crosses the blood-brain barrier directly without requiring enzymatic reduction by methylenetetrahydrofolate reductase (MTHFR). Transports one-carbon units for purine and thymidylate synthesis, essential for DNA replication, cell division, and homocysteine remethylation. Indicated for prevention of neural tube defects (spina bifida, anencephaly) in pregnancy, treatment of folate deficiency megaloblastic anemia, hyperhomocysteinemia, and adjunctive therapy in depression.

Vitamin B-Complex Formulations (Tablets, Capsules with Zinc, Syrup, and Injection) is a balanced formulation of essential B-group vitamins (B1 Thiamine, B2 Riboflavin, B3 Niacinamide, B5 Calcium Pantothenate, B6 Pyridoxine, B9 Folic Acid, B12 Cobalamin) on the WHO Model List of Essential Medicines. B-vitamins act as critical water-soluble coenzymes in cellular Krebs cycle energy production, carbohydrate and lipid metabolism, erythropoiesis, and myelin integrity. Indicated for prevention and treatment of generalized B-complex deficiencies, aphthous stomatitis/glossitis/angular cheilitis, convalescence, chronic debilitating illness, and nutritional maintenance during prolonged antibiotic therapy.

Pyridoxine Hydrochloride Tablets (50mg, 100mg, 100mg Sustained Release) is an oral Vitamin B6 formulation on the WHO Model List of Essential Medicines. Converted to pyridoxal-5-phosphate (PLP), an essential cofactor for over 140 enzymatic reactions including synthesis of neurotransmitters (GABA, serotonin, dopamine) and heme synthesis. Indicated for prevention and treatment of drug-induced peripheral neuropathy (from isoniazid, cycloserine, penicillamine), pyridoxine-dependent seizures in infants, idiopathic morning sickness, and sideroblastic anemia.

Methylcobalamin / Mecobalamin Tablets (500mcg, 1500mcg) and Orally Disintegrating Strips (1500mcg; alone or with Alpha Lipoic Acid, Benfotiamine, Folic Acid, Pyridoxine) is an active neurotropic coenzyme form of vitamin B12 on the WHO Model List framework. It functions as a methyl donor in homocysteine-to-methionine conversion, essential for phosphatidylcholine and myelin sheath synthesis, nucleic acid synthesis, and nerve regeneration. Indicated for diabetic peripheral neuropathy, alcoholic neuropathy, megaloblastic anemia, drug-induced neuropathy (isoniazid, metformin), and sciatica.

Calcitriol Capsules (0.25mcg; alone or in bone complexes with Calcium, Vitamin K2-7, Zinc) is the biologically active hormonal form of vitamin D3 (1,25-dihydroxycholecalciferol) on the WHO Model List of Essential Medicines. Unlike cholecalciferol, it requires no metabolic activation by the liver or kidneys, directly activating intestinal calcium absorption and bone remodeling. Indicated for management of hypocalcemia and renal osteodystrophy in patients with chronic kidney disease, hypoparathyroidism, pseudohypoparathyroidism, and severe osteoporosis.

Pyridoxine Hydrochloride Tablets (50mg, 100mg, 100mg Sustained Release) is an oral Vitamin B6 formulation on the WHO Model List of Essential Medicines. Converted to pyridoxal-5-phosphate (PLP), an essential cofactor for over 140 enzymatic reactions including synthesis of neurotransmitters (GABA, serotonin, dopamine) and heme synthesis. Indicated for prevention and treatment of drug-induced peripheral neuropathy (from isoniazid, cycloserine, penicillamine), pyridoxine-dependent seizures in infants, idiopathic morning sickness, and sideroblastic anemia.

Folic Acid (5mg, 15mg) and L-Methylfolate Calcium (1mg, 2.8mg, 7.5mg Tablets) is an essential water-soluble B-vitamin and active tetrahydrofolate derivative on the WHO Model List of Essential Medicines. L-Methylfolate is the active methylated metabolite (5-MTHF) that crosses the blood-brain barrier directly without requiring enzymatic reduction by methylenetetrahydrofolate reductase (MTHFR). Transports one-carbon units for purine and thymidylate synthesis, essential for DNA replication, cell division, and homocysteine remethylation. Indicated for prevention of neural tube defects (spina bifida, anencephaly) in pregnancy, treatment of folate deficiency megaloblastic anemia, hyperhomocysteinemia, and adjunctive therapy in depression.

Oral Iron and Folic Acid Formulations (Ferrous Ascorbate 100mg, Carbonyl Iron 50mg/100mg, Ferrous Asparto Glycinate with Folic Acid 1.5mg, L-Methylfolate, Zinc, and Vitamin B12) is an evidence-based hematinic on the WHO Model List of Essential Medicines. Ferrous ascorbate combines synthetic ascorbic acid (vitamin C) with divalent iron (Fe2+), maintaining iron in its soluble, highly absorbable ferrous state across duodenal pH and dramatically enhancing bioavailability while minimizing gastric mucosal irritation. Carbonyl iron provides ultra-pure elemental iron with delayed gastric acid dissolution, virtually eliminating nausea and toxicity. Folic acid and B12 support DNA synthesis and normoblastic erythropoiesis. Indicated for prevention and treatment of iron deficiency anemia, nutritional deficiency in pregnancy and lactation, and chronic menorrhagia.

Methylcobalamin / Mecobalamin Tablets (500mcg, 1500mcg) and Orally Disintegrating Strips (1500mcg; alone or with Alpha Lipoic Acid, Benfotiamine, Folic Acid, Pyridoxine) is an active neurotropic coenzyme form of vitamin B12 on the WHO Model List framework. It functions as a methyl donor in homocysteine-to-methionine conversion, essential for phosphatidylcholine and myelin sheath synthesis, nucleic acid synthesis, and nerve regeneration. Indicated for diabetic peripheral neuropathy, alcoholic neuropathy, megaloblastic anemia, drug-induced neuropathy (isoniazid, metformin), and sciatica.

Calcium Acetate Tablets (667mg, providing 169mg elemental calcium) is an oral intestinal phosphate binder on the WHO Model List framework. In the acidic stomach and duodenum, calcium acetate binds dietary phosphorus to form insoluble calcium phosphate complexes that are excreted in feces, preventing phosphate absorption without excessive calcium absorption. Indicated for control of hyperphosphatemia in adult and pediatric patients with End-Stage Renal Disease (ESRD) / Chronic Kidney Disease on hemodialysis.

Calcium Formulations (Calcium Carbonate 500mg/1250mg, Calcium Citrate Malate 250mg/1000mg, Coral Calcium with Vitamin D3 250-2000 IU, Vitamin K2-7, Magnesium, and Zinc) is an oral bone remineralization complex on the WHO Model List of Essential Medicines. Calcium provides elemental bone mineral matrix; vitamin D3 stimulates intestinal calcium transport; vitamin K2-7 (menaquinone-7) activates osteocalcin to bind calcium into hydroxyapatite crystals while preventing ectopic arterial vascular calcification; zinc and magnesium act as essential osteoblast cofactors. Indicated for prevention and treatment of postmenopausal osteoporosis, osteopenia, pregnancy/lactation calcium demands, and bone fracture healing.

Folic Acid (5mg, 15mg) and L-Methylfolate Calcium (1mg, 2.8mg, 7.5mg Tablets) is an essential water-soluble B-vitamin and active tetrahydrofolate derivative on the WHO Model List of Essential Medicines. L-Methylfolate is the active methylated metabolite (5-MTHF) that crosses the blood-brain barrier directly without requiring enzymatic reduction by methylenetetrahydrofolate reductase (MTHFR). Transports one-carbon units for purine and thymidylate synthesis, essential for DNA replication, cell division, and homocysteine remethylation. Indicated for prevention of neural tube defects (spina bifida, anencephaly) in pregnancy, treatment of folate deficiency megaloblastic anemia, hyperhomocysteinemia, and adjunctive therapy in depression.

Pyridoxine Hydrochloride Tablets (50mg, 100mg, 100mg Sustained Release) is an oral Vitamin B6 formulation on the WHO Model List of Essential Medicines. Converted to pyridoxal-5-phosphate (PLP), an essential cofactor for over 140 enzymatic reactions including synthesis of neurotransmitters (GABA, serotonin, dopamine) and heme synthesis. Indicated for prevention and treatment of drug-induced peripheral neuropathy (from isoniazid, cycloserine, penicillamine), pyridoxine-dependent seizures in infants, idiopathic morning sickness, and sideroblastic anemia.

Calcitriol Capsules (0.25mcg; alone or in bone complexes with Calcium, Vitamin K2-7, Zinc) is the biologically active hormonal form of vitamin D3 (1,25-dihydroxycholecalciferol) on the WHO Model List of Essential Medicines. Unlike cholecalciferol, it requires no metabolic activation by the liver or kidneys, directly activating intestinal calcium absorption and bone remodeling. Indicated for management of hypocalcemia and renal osteodystrophy in patients with chronic kidney disease, hypoparathyroidism, pseudohypoparathyroidism, and severe osteoporosis.

Oral Iron and Folic Acid Formulations (Ferrous Ascorbate 100mg, Carbonyl Iron 50mg/100mg, Ferrous Asparto Glycinate with Folic Acid 1.5mg, L-Methylfolate, Zinc, and Vitamin B12) is an evidence-based hematinic on the WHO Model List of Essential Medicines. Ferrous ascorbate combines synthetic ascorbic acid (vitamin C) with divalent iron (Fe2+), maintaining iron in its soluble, highly absorbable ferrous state across duodenal pH and dramatically enhancing bioavailability while minimizing gastric mucosal irritation. Carbonyl iron provides ultra-pure elemental iron with delayed gastric acid dissolution, virtually eliminating nausea and toxicity. Folic acid and B12 support DNA synthesis and normoblastic erythropoiesis. Indicated for prevention and treatment of iron deficiency anemia, nutritional deficiency in pregnancy and lactation, and chronic menorrhagia.

Ginseng + Multivitamins + multiminerals Capsules is an established pharmaceutical and nutritional agent in the Vitamins, Minerals & Nutrition category on the PMBI National Formulary. Formulated to provide micronutrient replenishment, metabolic support, or nutritional therapy according to verified pharmacopoeial standards.

Calcitriol Capsules (0.25mcg; alone or in bone complexes with Calcium, Vitamin K2-7, Zinc) is the biologically active hormonal form of vitamin D3 (1,25-dihydroxycholecalciferol) on the WHO Model List of Essential Medicines. Unlike cholecalciferol, it requires no metabolic activation by the liver or kidneys, directly activating intestinal calcium absorption and bone remodeling. Indicated for management of hypocalcemia and renal osteodystrophy in patients with chronic kidney disease, hypoparathyroidism, pseudohypoparathyroidism, and severe osteoporosis.

Methylcobalamin / Mecobalamin Tablets (500mcg, 1500mcg) and Orally Disintegrating Strips (1500mcg; alone or with Alpha Lipoic Acid, Benfotiamine, Folic Acid, Pyridoxine) is an active neurotropic coenzyme form of vitamin B12 on the WHO Model List framework. It functions as a methyl donor in homocysteine-to-methionine conversion, essential for phosphatidylcholine and myelin sheath synthesis, nucleic acid synthesis, and nerve regeneration. Indicated for diabetic peripheral neuropathy, alcoholic neuropathy, megaloblastic anemia, drug-induced neuropathy (isoniazid, metformin), and sciatica.

Oral Iron and Folic Acid Formulations (Ferrous Ascorbate 100mg, Carbonyl Iron 50mg/100mg, Ferrous Asparto Glycinate with Folic Acid 1.5mg, L-Methylfolate, Zinc, and Vitamin B12) is an evidence-based hematinic on the WHO Model List of Essential Medicines. Ferrous ascorbate combines synthetic ascorbic acid (vitamin C) with divalent iron (Fe2+), maintaining iron in its soluble, highly absorbable ferrous state across duodenal pH and dramatically enhancing bioavailability while minimizing gastric mucosal irritation. Carbonyl iron provides ultra-pure elemental iron with delayed gastric acid dissolution, virtually eliminating nausea and toxicity. Folic acid and B12 support DNA synthesis and normoblastic erythropoiesis. Indicated for prevention and treatment of iron deficiency anemia, nutritional deficiency in pregnancy and lactation, and chronic menorrhagia.

Thiamine Hydrochloride Tablets (100mg) is an oral Vitamin B1 preparation on the WHO Model List of Essential Medicines for prevention and treatment of thiamine deficiency, dry and wet beriberi, and nutritional support in chronic alcoholism.

Methylcobalamin / Mecobalamin Tablets (500mcg, 1500mcg) and Orally Disintegrating Strips (1500mcg; alone or with Alpha Lipoic Acid, Benfotiamine, Folic Acid, Pyridoxine) is an active neurotropic coenzyme form of vitamin B12 on the WHO Model List framework. It functions as a methyl donor in homocysteine-to-methionine conversion, essential for phosphatidylcholine and myelin sheath synthesis, nucleic acid synthesis, and nerve regeneration. Indicated for diabetic peripheral neuropathy, alcoholic neuropathy, megaloblastic anemia, drug-induced neuropathy (isoniazid, metformin), and sciatica.

Diacerein Capsules (50mg; alone or with Glucosamine Sulphate 500mg/750mg) is an anthraquinone-derivative symptomatic slow-acting drug in osteoarthritis (SYSADOA) on the PMBI formulary. It is metabolized to rhein, which potently and selectively inhibits the synthesis and activity of Interleukin-1beta (IL-1beta), the master cytokine driving cartilage degradation and synovial inflammation. It downregulates matrix metalloproteinases (MMP-1, MMP-3, MMP-13) and stimulates chondrocyte synthesis of proteoglycans, aggrecan, and hyaluronic acid without inhibiting cyclooxygenase or causing gastric ulceration. Indicated for symptomatic treatment of osteoarthritis of the knee and hip.

L-Lysine + Multivitamins (Vit-B1 + B2 + B3 + B5 + B6 ) Syrup is an established pharmaceutical and nutritional agent in the Vitamins, Minerals & Nutrition category on the PMBI National Formulary. Formulated to provide micronutrient replenishment, metabolic support, or nutritional therapy according to verified pharmacopoeial standards.

Lycopene with Multivitamins + Multi Minerals Syrup is an established pharmaceutical and nutritional agent in the Vitamins, Minerals & Nutrition category on the PMBI National Formulary. Formulated to provide micronutrient replenishment, metabolic support, or nutritional therapy according to verified pharmacopoeial standards.

Diacerein Capsules (50mg; alone or with Glucosamine Sulphate 500mg/750mg) is an anthraquinone-derivative symptomatic slow-acting drug in osteoarthritis (SYSADOA) on the PMBI formulary. It is metabolized to rhein, which potently and selectively inhibits the synthesis and activity of Interleukin-1beta (IL-1beta), the master cytokine driving cartilage degradation and synovial inflammation. It downregulates matrix metalloproteinases (MMP-1, MMP-3, MMP-13) and stimulates chondrocyte synthesis of proteoglycans, aggrecan, and hyaluronic acid without inhibiting cyclooxygenase or causing gastric ulceration. Indicated for symptomatic treatment of osteoarthritis of the knee and hip.

Diacerein Capsules (50mg; alone or with Glucosamine Sulphate 500mg/750mg) is an anthraquinone-derivative symptomatic slow-acting drug in osteoarthritis (SYSADOA) on the PMBI formulary. It is metabolized to rhein, which potently and selectively inhibits the synthesis and activity of Interleukin-1beta (IL-1beta), the master cytokine driving cartilage degradation and synovial inflammation. It downregulates matrix metalloproteinases (MMP-1, MMP-3, MMP-13) and stimulates chondrocyte synthesis of proteoglycans, aggrecan, and hyaluronic acid without inhibiting cyclooxygenase or causing gastric ulceration. Indicated for symptomatic treatment of osteoarthritis of the knee and hip.

Calcitriol Capsules (0.25mcg; alone or in bone complexes with Calcium, Vitamin K2-7, Zinc) is the biologically active hormonal form of vitamin D3 (1,25-dihydroxycholecalciferol) on the WHO Model List of Essential Medicines. Unlike cholecalciferol, it requires no metabolic activation by the liver or kidneys, directly activating intestinal calcium absorption and bone remodeling. Indicated for management of hypocalcemia and renal osteodystrophy in patients with chronic kidney disease, hypoparathyroidism, pseudohypoparathyroidism, and severe osteoporosis.

Levocarnitine Tablets (500mg) and Injection (1g) is an oral and parenteral carrier molecule on the WHO Model List of Essential Medicines. It facilitates the transport of long-chain fatty acids across the inner mitochondrial membrane via carnitine palmitoyltransferase (CPT-1) for beta-oxidation and cellular energy synthesis, and removes toxic intracellular acyl compounds. Indicated for primary and secondary carnitine deficiency in end-stage renal disease (ESRD) patients on hemodialysis, metabolic organic acidurias, and valproic acid-induced hyperammonemic hepatotoxicity.

Calcium Formulations (Calcium Carbonate 500mg/1250mg, Calcium Citrate Malate 250mg/1000mg, Coral Calcium with Vitamin D3 250-2000 IU, Vitamin K2-7, Magnesium, and Zinc) is an oral bone remineralization complex on the WHO Model List of Essential Medicines. Calcium provides elemental bone mineral matrix; vitamin D3 stimulates intestinal calcium transport; vitamin K2-7 (menaquinone-7) activates osteocalcin to bind calcium into hydroxyapatite crystals while preventing ectopic arterial vascular calcification; zinc and magnesium act as essential osteoblast cofactors. Indicated for prevention and treatment of postmenopausal osteoporosis, osteopenia, pregnancy/lactation calcium demands, and bone fracture healing.

Methylcobalamin / Mecobalamin Tablets (500mcg, 1500mcg) and Orally Disintegrating Strips (1500mcg; alone or with Alpha Lipoic Acid, Benfotiamine, Folic Acid, Pyridoxine) is an active neurotropic coenzyme form of vitamin B12 on the WHO Model List framework. It functions as a methyl donor in homocysteine-to-methionine conversion, essential for phosphatidylcholine and myelin sheath synthesis, nucleic acid synthesis, and nerve regeneration. Indicated for diabetic peripheral neuropathy, alcoholic neuropathy, megaloblastic anemia, drug-induced neuropathy (isoniazid, metformin), and sciatica.

Calcitriol Capsules (0.25mcg; alone or in bone complexes with Calcium, Vitamin K2-7, Zinc) is the biologically active hormonal form of vitamin D3 (1,25-dihydroxycholecalciferol) on the WHO Model List of Essential Medicines. Unlike cholecalciferol, it requires no metabolic activation by the liver or kidneys, directly activating intestinal calcium absorption and bone remodeling. Indicated for management of hypocalcemia and renal osteodystrophy in patients with chronic kidney disease, hypoparathyroidism, pseudohypoparathyroidism, and severe osteoporosis.

Methylcobalamin / Mecobalamin Tablets (500mcg, 1500mcg) and Orally Disintegrating Strips (1500mcg; alone or with Alpha Lipoic Acid, Benfotiamine, Folic Acid, Pyridoxine) is an active neurotropic coenzyme form of vitamin B12 on the WHO Model List framework. It functions as a methyl donor in homocysteine-to-methionine conversion, essential for phosphatidylcholine and myelin sheath synthesis, nucleic acid synthesis, and nerve regeneration. Indicated for diabetic peripheral neuropathy, alcoholic neuropathy, megaloblastic anemia, drug-induced neuropathy (isoniazid, metformin), and sciatica.

Methylcobalamin / Mecobalamin Tablets (500mcg, 1500mcg) and Orally Disintegrating Strips (1500mcg; alone or with Alpha Lipoic Acid, Benfotiamine, Folic Acid, Pyridoxine) is an active neurotropic coenzyme form of vitamin B12 on the WHO Model List framework. It functions as a methyl donor in homocysteine-to-methionine conversion, essential for phosphatidylcholine and myelin sheath synthesis, nucleic acid synthesis, and nerve regeneration. Indicated for diabetic peripheral neuropathy, alcoholic neuropathy, megaloblastic anemia, drug-induced neuropathy (isoniazid, metformin), and sciatica.

Methylcobalamin / Mecobalamin Tablets (500mcg, 1500mcg) and Orally Disintegrating Strips (1500mcg; alone or with Alpha Lipoic Acid, Benfotiamine, Folic Acid, Pyridoxine) is an active neurotropic coenzyme form of vitamin B12 on the WHO Model List framework. It functions as a methyl donor in homocysteine-to-methionine conversion, essential for phosphatidylcholine and myelin sheath synthesis, nucleic acid synthesis, and nerve regeneration. Indicated for diabetic peripheral neuropathy, alcoholic neuropathy, megaloblastic anemia, drug-induced neuropathy (isoniazid, metformin), and sciatica.

Glucosamine Formulations (500mg, 750mg, 1500mg Tablets; alone or with Chondroitin 400mg, Diacerein 50mg, or Methylsulfonylmethane MSM 250mg) is an oral amino monosaccharide cartilage supplement on the PMBI formulary. Glucosamine serves as an essential biochemical building block for the synthesis of glycosaminoglycans (GAGs), proteoglycans, and hyaluronic acid in the articular cartilage matrix and synovial fluid. Chondroitin inhibits elastase and hyaluronidase enzymes; MSM provides organic sulfur for connective tissue cross-linking. Indicated for symptomatic relief of mild-to-moderate osteoarthritis of the knee and joints.

Glucosamine Formulations (500mg, 750mg, 1500mg Tablets; alone or with Chondroitin 400mg, Diacerein 50mg, or Methylsulfonylmethane MSM 250mg) is an oral amino monosaccharide cartilage supplement on the PMBI formulary. Glucosamine serves as an essential biochemical building block for the synthesis of glycosaminoglycans (GAGs), proteoglycans, and hyaluronic acid in the articular cartilage matrix and synovial fluid. Chondroitin inhibits elastase and hyaluronidase enzymes; MSM provides organic sulfur for connective tissue cross-linking. Indicated for symptomatic relief of mild-to-moderate osteoarthritis of the knee and joints.

Methylcobalamin / Mecobalamin Tablets (500mcg, 1500mcg) and Orally Disintegrating Strips (1500mcg; alone or with Alpha Lipoic Acid, Benfotiamine, Folic Acid, Pyridoxine) is an active neurotropic coenzyme form of vitamin B12 on the WHO Model List framework. It functions as a methyl donor in homocysteine-to-methionine conversion, essential for phosphatidylcholine and myelin sheath synthesis, nucleic acid synthesis, and nerve regeneration. Indicated for diabetic peripheral neuropathy, alcoholic neuropathy, megaloblastic anemia, drug-induced neuropathy (isoniazid, metformin), and sciatica.

Glucosamine 750mg & Chondroitin 100mg Tablets is an established pharmaceutical and nutritional agent in the Vitamins, Minerals & Nutrition category on the PMBI National Formulary. Formulated to provide micronutrient replenishment, metabolic support, or nutritional therapy according to verified pharmacopoeial standards.

Glucosamine Formulations (500mg, 750mg, 1500mg Tablets; alone or with Chondroitin 400mg, Diacerein 50mg, or Methylsulfonylmethane MSM 250mg) is an oral amino monosaccharide cartilage supplement on the PMBI formulary. Glucosamine serves as an essential biochemical building block for the synthesis of glycosaminoglycans (GAGs), proteoglycans, and hyaluronic acid in the articular cartilage matrix and synovial fluid. Chondroitin inhibits elastase and hyaluronidase enzymes; MSM provides organic sulfur for connective tissue cross-linking. Indicated for symptomatic relief of mild-to-moderate osteoarthritis of the knee and joints.

Thiamine Hydrochloride Tablets (100mg) is an oral Vitamin B1 preparation on the WHO Model List of Essential Medicines for prevention and treatment of thiamine deficiency, dry and wet beriberi, and nutritional support in chronic alcoholism.

Calcium Formulations (Calcium Carbonate 500mg/1250mg, Calcium Citrate Malate 250mg/1000mg, Coral Calcium with Vitamin D3 250-2000 IU, Vitamin K2-7, Magnesium, and Zinc) is an oral bone remineralization complex on the WHO Model List of Essential Medicines. Calcium provides elemental bone mineral matrix; vitamin D3 stimulates intestinal calcium transport; vitamin K2-7 (menaquinone-7) activates osteocalcin to bind calcium into hydroxyapatite crystals while preventing ectopic arterial vascular calcification; zinc and magnesium act as essential osteoblast cofactors. Indicated for prevention and treatment of postmenopausal osteoporosis, osteopenia, pregnancy/lactation calcium demands, and bone fracture healing.

Folic Acid (5mg, 15mg) and L-Methylfolate Calcium (1mg, 2.8mg, 7.5mg Tablets) is an essential water-soluble B-vitamin and active tetrahydrofolate derivative on the WHO Model List of Essential Medicines. L-Methylfolate is the active methylated metabolite (5-MTHF) that crosses the blood-brain barrier directly without requiring enzymatic reduction by methylenetetrahydrofolate reductase (MTHFR). Transports one-carbon units for purine and thymidylate synthesis, essential for DNA replication, cell division, and homocysteine remethylation. Indicated for prevention of neural tube defects (spina bifida, anencephaly) in pregnancy, treatment of folate deficiency megaloblastic anemia, hyperhomocysteinemia, and adjunctive therapy in depression.