TabletsClinical Overview
Diacerein Capsules (50mg; alone or with Glucosamine Sulphate 500mg/750mg) is an anthraquinone-derivative symptomatic slow-acting drug in osteoarthritis (SYSADOA) on the PMBI formulary. It is metabolized to rhein, which potently and selectively inhibits the synthesis and activity of Interleukin-1beta (IL-1beta), the master cytokine driving cartilage degradation and synovial inflammation. It downregulates matrix metalloproteinases (MMP-1, MMP-3, MMP-13) and stimulates chondrocyte synthesis of proteoglycans, aggrecan, and hyaluronic acid without inhibiting cyclooxygenase or causing gastric ulceration. Indicated for symptomatic treatment of osteoarthritis of the knee and hip.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally 50 mg once daily with the evening meal for the first 2 to 4 weeks (to minimize laxative-induced diarrhea), then increase to 50 mg twice daily with meals with water. Clinical onset is delayed (requires 4 to 8 weeks for therapeutic benefit). Swallow whole.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Diarrhea / loose stools (occurs in up to 30-40% during initial weeks), abdominal pain, harmless dark yellow to orange discoloration of urine. Rare/Severe: Severe diarrhea with dehydration, and hepatotoxicity (elevated transaminases).
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Contraindicated in patients with inflammatory bowel disease (Crohn's, ulcerative colitis), intestinal obstruction, or pre-existing liver disease. Discontinue immediately if severe persistent diarrhea occurs. In elderly patients (>65 years), start at 50 mg daily and monitor closely.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or analgesic treatment guidance. Always consult a registered physician or orthopedic specialist before taking pain relievers, anti-inflammatory medications, or anti-arthritic therapies.
Pyridoxine Hydrochloride 10mg, Doxylamine 10mg and Folic Acid 2.5mg Tablets
Folic Acid (5mg, 15mg) and L-Methylfolate Calcium (1mg, 2.8mg, 7.5mg Tablets) is an essential water-soluble B-vitamin and active tetrahydrofolate derivative on the WHO Model List of Essential Medicines. L-Methylfolate is the active methylated metabolite (5-MTHF) that crosses the blood-brain barrier directly without requiring enzymatic reduction by methylenetetrahydrofolate reductase (MTHFR). Transports one-carbon units for purine and thymidylate synthesis, essential for DNA replication, cell division, and homocysteine remethylation. Indicated for prevention of neural tube defects (spina bifida, anencephaly) in pregnancy, treatment of folate deficiency megaloblastic anemia, hyperhomocysteinemia, and adjunctive therapy in depression.
Folic Acid Tablets 5 mg
Folic Acid (5mg, 15mg) and L-Methylfolate Calcium (1mg, 2.8mg, 7.5mg Tablets) is an essential water-soluble B-vitamin and active tetrahydrofolate derivative on the WHO Model List of Essential Medicines. L-Methylfolate is the active methylated metabolite (5-MTHF) that crosses the blood-brain barrier directly without requiring enzymatic reduction by methylenetetrahydrofolate reductase (MTHFR). Transports one-carbon units for purine and thymidylate synthesis, essential for DNA replication, cell division, and homocysteine remethylation. Indicated for prevention of neural tube defects (spina bifida, anencephaly) in pregnancy, treatment of folate deficiency megaloblastic anemia, hyperhomocysteinemia, and adjunctive therapy in depression.
Syrup of Iron and Folic Acid in a flavoured Base
Oral Iron and Folic Acid Formulations (Ferrous Ascorbate 100mg, Carbonyl Iron 50mg/100mg, Ferrous Asparto Glycinate with Folic Acid 1.5mg, L-Methylfolate, Zinc, and Vitamin B12) is an evidence-based hematinic on the WHO Model List of Essential Medicines. Ferrous ascorbate combines synthetic ascorbic acid (vitamin C) with divalent iron (Fe2+), maintaining iron in its soluble, highly absorbable ferrous state across duodenal pH and dramatically enhancing bioavailability while minimizing gastric mucosal irritation. Carbonyl iron provides ultra-pure elemental iron with delayed gastric acid dissolution, virtually eliminating nausea and toxicity. Folic acid and B12 support DNA synthesis and normoblastic erythropoiesis. Indicated for prevention and treatment of iron deficiency anemia, nutritional deficiency in pregnancy and lactation, and chronic menorrhagia.
Polyvitamin Tablets NFI (Prophylactic)
Vitamin B-Complex Formulations (Tablets, Capsules with Zinc, Syrup, and Injection) is a balanced formulation of essential B-group vitamins (B1 Thiamine, B2 Riboflavin, B3 Niacinamide, B5 Calcium Pantothenate, B6 Pyridoxine, B9 Folic Acid, B12 Cobalamin) on the WHO Model List of Essential Medicines. B-vitamins act as critical water-soluble coenzymes in cellular Krebs cycle energy production, carbohydrate and lipid metabolism, erythropoiesis, and myelin integrity. Indicated for prevention and treatment of generalized B-complex deficiencies, aphthous stomatitis/glossitis/angular cheilitis, convalescence, chronic debilitating illness, and nutritional maintenance during prolonged antibiotic therapy.