Clinical Overview
Pyridoxine Hydrochloride Tablets (50mg, 100mg, 100mg Sustained Release) is an oral Vitamin B6 formulation on the WHO Model List of Essential Medicines. Converted to pyridoxal-5-phosphate (PLP), an essential cofactor for over 140 enzymatic reactions including synthesis of neurotransmitters (GABA, serotonin, dopamine) and heme synthesis. Indicated for prevention and treatment of drug-induced peripheral neuropathy (from isoniazid, cycloserine, penicillamine), pyridoxine-dependent seizures in infants, idiopathic morning sickness, and sideroblastic anemia.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally 50 mg to 100 mg once daily with water, with or without food. Isoniazid neuropathy prophylaxis: take 10 to 50 mg daily concurrently with anti-TB therapy.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Safe at standard therapeutic doses (<100 mg/day). Chronic megadose toxicity (>200-500 mg daily for months): Sensory peripheral neuropathy, ataxia, and numbness.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Over-The-Counter vitamin. Avoid excessive chronic doses (>100 mg/day for prolonged periods) to prevent pyridoxine-induced sensory ataxia and peripheral neuropathy.
Medical Disclaimer: Statutory Nutritional & Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice or clinical dietetic guidance. Dietary supplements, micronutrients, parenteral electrolytes, and specialized clinical nutrition should be used under the supervision of a registered medical practitioner or clinical nutritionist.