TabletsClinical Overview
Mebeverine Hydrochloride (135mg) and Chlordiazepoxide (5mg) Tablets is a fixed combination musculotropic antispasmodic and anxiolytic. Mebeverine acts directly on colonic smooth muscle cells, blocking voltage-operated sodium channels and preventing calcium influx without systemic anticholinergic effects. Chlordiazepoxide is a benzodiazepine that enhances GABAergic inhibitory neurotransmission in the limbic system, reducing visceral hyperalgesia and brain-gut axis anxiety. Indicated for irritable bowel syndrome (IBS) exacerbated by stress, anxiety-related spastic colon, and functional abdominal cramping.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally 1 tablet three times daily, 20 minutes before meals with a glass of water. Swallow whole; do not chew. Avoid alcohol.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Drowsiness, dizziness, dry mouth, ataxia, mild constipation. Rare/Severe: Physical dependence and withdrawal syndrome upon abrupt cessation, respiratory depression, and severe allergic reactions.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Schedule H1 Controlled Substance: Contains chlordiazepoxide (benzodiazepine); risk of abuse, tolerance, and physical dependence. Strictly avoid alcohol. Contraindicated in myasthenia gravis, severe respiratory insufficiency, and sleep apnea.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or gastrointestinal treatment recommendations. Always consult a registered gastroenterologist or qualified medical practitioner before initiating, altering, or discontinuing any gastrointestinal medication or digestive therapy.
Chlordiazepoxide 10mg + Trifluoperazine 1mg Tablets
Chlordiazepoxide and Trifluoperazine combines an anxiolytic benzodiazepine with a high-potency phenothiazine antipsychotic. Trifluoperazine blocks postsynaptic dopamine D2 receptors in the mesolimbic pathway, subduing agitation and delusional thinking, while chlordiazepoxide modulates GABAA receptors to control anxiety and somatic tension. Indicated for anxiety states complicated by somatic obsessions, severe agitation, or mild psychotic symptoms.
Chlordiazepoxide Tablets 10 mg
Chlordiazepoxide is the historical first-discovered benzodiazepine. It acts by binding to stereospecific GABAA receptors in the central nervous system, enhancing chloride ion channel opening and augmenting GABA-mediated neuronal inhibition. Possesses active metabolites with a long elimination half-life. Indicated for short-term relief of severe anxiety disorders and acute management of alcohol withdrawal symptoms.
Mebeverine Hydrochloride Tablets 200mg
Mebeverine Hydrochloride Tablets (200mg) is an oral direct musculotropic antispasmodic on the WHO Model List framework. It normalizes colonic motility by selectively blocking sodium channels and inhibiting intracellular calcium influx and muscarinic depolarization on intestinal smooth muscle cells without anticholinergic side effects. Indicated for irritable bowel syndrome (IBS) characterized by abdominal pain, cramping, bloating, and alternating diarrhea and constipation.
Chlordiazepoxide 5mg + Amitriptyline Hydrochloride 12.5mg Tablets
Chlordiazepoxide and Amitriptyline is a classic psychotropic formulation combining a benzodiazepine with a tricyclic antidepressant (TCA). Chlordiazepoxide provides prompt reduction of psychic tension, anxiety, and agitation via GABAA receptor enhancement, while amitriptyline inhibits the neuronal reuptake of norepinephrine and serotonin to resolve underlying depressive illness. Indicated for moderate-to-severe depression associated with prominent anxiety, agitation, and insomnia.