TabletsClinical Overview
Mebeverine Hydrochloride Tablets (200mg) is an oral direct musculotropic antispasmodic on the WHO Model List framework. It normalizes colonic motility by selectively blocking sodium channels and inhibiting intracellular calcium influx and muscarinic depolarization on intestinal smooth muscle cells without anticholinergic side effects. Indicated for irritable bowel syndrome (IBS) characterized by abdominal pain, cramping, bloating, and alternating diarrhea and constipation.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally 200 mg twice daily (morning and evening), 20 minutes before meals with a full glass of water. Swallow whole; do not crush or chew prolonged-release formulations.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Mild headache, dizziness, nausea, flatulence, constipation. Rare/Severe: Urticaria, angioedema, face edema, and exanthema. No anticholinergic dry mouth, urinary retention, or blurred vision.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Contraindicated in paralytic ileus. Safe for use in patients with glaucoma or prostatic hypertrophy who cannot tolerate atropine-like antispasmodics.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or gastrointestinal treatment recommendations. Always consult a registered gastroenterologist or qualified medical practitioner before initiating, altering, or discontinuing any gastrointestinal medication or digestive therapy.