TabletsClinical Overview
Chlordiazepoxide and Amitriptyline is a classic psychotropic formulation combining a benzodiazepine with a tricyclic antidepressant (TCA). Chlordiazepoxide provides prompt reduction of psychic tension, anxiety, and agitation via GABAA receptor enhancement, while amitriptyline inhibits the neuronal reuptake of norepinephrine and serotonin to resolve underlying depressive illness. Indicated for moderate-to-severe depression associated with prominent anxiety, agitation, and insomnia.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally with water, preferably at bedtime to minimize daytime sedation and anticholinergic effects, with or without food. Taper dosage gradually when discontinuing.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Sedation, dry mouth, blurred vision, constipation, weight gain, dizziness, urinary retention. Rare/Severe: Cardiac arrhythmias (prolonged QTc, heart block), suicidal ideation, orthostatic hypotension, seizures, and dependence.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Contraindicated in acute recovery post-myocardial infarction, severe hepatic disease, and concurrent MAOIs. Exercise caution in glaucoma, urinary retention, and the elderly. Avoid alcohol.
Schedule H1 (Prescription Required - Habit Forming Warning)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified pharmacist before initiating, modifying, or substituting any medication regimen.
Amitriptyline Hydrochloride Tablets 25mg
Amitriptyline Hydrochloride is a prototype dibenzocycloheptadiene tricyclic antidepressant (TCA) on the WHO Model List of Essential Medicines. It inhibits the presynaptic neuronal reuptake of norepinephrine and serotonin, while also antagonizing muscarinic, histaminergic H1, and alpha-1 adrenergic receptors, and blocking neuronal sodium channels. Indicated for major depressive disorder, neuropathic pain (diabetic neuropathy, post-herpetic neuralgia), chronic tension-type headache and migraine prophylaxis, and nocturnal enuresis in children.
Amitriptyline Hydrochloride Tablets 10mg
Amitriptyline Hydrochloride is a prototype dibenzocycloheptadiene tricyclic antidepressant (TCA) on the WHO Model List of Essential Medicines. It inhibits the presynaptic neuronal reuptake of norepinephrine and serotonin, while also antagonizing muscarinic, histaminergic H1, and alpha-1 adrenergic receptors, and blocking neuronal sodium channels. Indicated for major depressive disorder, neuropathic pain (diabetic neuropathy, post-herpetic neuralgia), chronic tension-type headache and migraine prophylaxis, and nocturnal enuresis in children.
Chlordiazepoxide 10mg + Trifluoperazine 1mg Tablets
Chlordiazepoxide and Trifluoperazine combines an anxiolytic benzodiazepine with a high-potency phenothiazine antipsychotic. Trifluoperazine blocks postsynaptic dopamine D2 receptors in the mesolimbic pathway, subduing agitation and delusional thinking, while chlordiazepoxide modulates GABAA receptors to control anxiety and somatic tension. Indicated for anxiety states complicated by somatic obsessions, severe agitation, or mild psychotic symptoms.
Gabapentin 300mg + Amitriptyline 10mg Tablets
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