Antimalarials

alpha-beta Arteether is an ethyl ether derivative of artemisinin formulated in an oily injectable vehicle. It exerts potent, rapid schizontocidal activity against erythrocytic stages of Plasmodium falciparum and Plasmodium vivax via endoperoxide radical-mediated damage to parasite membranes. Indicated for severe falciparum malaria, cerebral malaria, and chloroquine-resistant malaria.

Chloroquine Phosphate is a 4-aminoquinoline antimalarial and antirheumatic agent. It accumulates within the acidic food vacuole of the malaria parasite, inhibiting the biocrystallization of toxic heme into non-toxic hemozoin; uncomplexed heme lyses parasite membranes. Indicated for the treatment and prophylaxis of malaria caused by susceptible Plasmodium vivax, P. malariae, and P. ovale, as well as extraintestinal amoebiasis (amoebic liver abscess).

Artesunate is a water-soluble hemisuccinate derivative of artemisinin and the WHO gold-standard first-line treatment for severe malaria. Its endoperoxide bridge is cleaved by intraparasitic heme-iron, generating free radicals that alkylate essential parasitic proteins and PfATP6, rapidly reducing parasite biomass within hours. Indicated parenterally for severe Plasmodium falciparum and vivax malaria, cerebral malaria, and complicated malarial infections.

Quinine Sulphate is a cinchona alkaloid schizontocidal antimalarial agent. It acts primarily on the asexual erythrocytic forms of all Plasmodium species by interfering with hemozoin synthesis and parasite digestion of hemoglobin. Indicated for uncomplicated and severe chloroquine-resistant Plasmodium falciparum malaria and nocturnal leg cramps (unlabeled, restricted due to toxicity).

Hydroxychloroquine Sulfate is a 4-aminoquinoline derivative related to chloroquine with improved ocular safety. It concentrates in cellular lysosomes, increasing intralysosomal pH and interfering with antigen processing, Toll-like receptor signaling, and production of pro-inflammatory cytokines. Indicated for systemic lupus erythematosus (SLE), rheumatoid arthritis, discoid lupus, and malaria treatment/chemoprophylaxis in chloroquine-sensitive areas.

Mefloquine Hydrochloride Tablets 250mg is a targeted anti-infective pharmaceutical formulation indicated for the treatment and prophylaxis of susceptible bacterial, fungal, protozoal, or viral infections. It exerts evidence-based therapeutic action by disrupting microbial cellular processes, inhibiting structural synthesis, or neutralizing infectious pathogens.

Artemether and Lumefantrine is a premier oral Artemisinin-based Combination Therapy (ACT) on the WHO Model List of Essential Medicines. Artemether provides fast clearance of parasitemia through free radical production, while lumefantrine, a synthetic fluorene derivative, clears remaining parasites with a prolonged elimination half-life, preventing recrudescence and resistance development. Indicated for the treatment of acute uncomplicated Plasmodium falciparum and mixed malaria.

Hydroxychloroquine Sulfate is a 4-aminoquinoline derivative related to chloroquine with improved ocular safety. It concentrates in cellular lysosomes, increasing intralysosomal pH and interfering with antigen processing, Toll-like receptor signaling, and production of pro-inflammatory cytokines. Indicated for systemic lupus erythematosus (SLE), rheumatoid arthritis, discoid lupus, and malaria treatment/chemoprophylaxis in chloroquine-sensitive areas.

Artesunate is a water-soluble hemisuccinate derivative of artemisinin and the WHO gold-standard first-line treatment for severe malaria. Its endoperoxide bridge is cleaved by intraparasitic heme-iron, generating free radicals that alkylate essential parasitic proteins and PfATP6, rapidly reducing parasite biomass within hours. Indicated parenterally for severe Plasmodium falciparum and vivax malaria, cerebral malaria, and complicated malarial infections.

alpha-beta Arteether is an ethyl ether derivative of artemisinin formulated in an oily injectable vehicle. It exerts potent, rapid schizontocidal activity against erythrocytic stages of Plasmodium falciparum and Plasmodium vivax via endoperoxide radical-mediated damage to parasite membranes. Indicated for severe falciparum malaria, cerebral malaria, and chloroquine-resistant malaria.

Artesunate, Sulfadoxine, and Pyrimethamine Combi Kit is a WHO-endorsed Artemisinin-based Combination Therapy (ACT). Artesunate acts rapidly to clear the bulk of malaria parasites by releasing reactive carbon-centered free radicals, while sulfadoxine (dihydropteroate synthase inhibitor) and pyrimethamine (dihydrofolate reductase inhibitor) provide synergistic long-acting anti-folate elimination of residual parasites. Indicated for the treatment of acute uncomplicated Plasmodium falciparum malaria.

Primaquine Phosphate is an 8-aminoquinoline antimalarial on the WHO Model List of Essential Medicines. It is the sole widely used drug that eliminates dormant liver hypnozoites of Plasmodium vivax and Plasmodium ovale, achieving radical cure and preventing relapses. Also exhibits gametocidal activity against P. falciparum, interrupting malaria transmission. Indicated for radical cure of vivax/ovale malaria and falciparum gametocytocidal therapy.

Primaquine Phosphate is an 8-aminoquinoline antimalarial on the WHO Model List of Essential Medicines. It is the sole widely used drug that eliminates dormant liver hypnozoites of Plasmodium vivax and Plasmodium ovale, achieving radical cure and preventing relapses. Also exhibits gametocidal activity against P. falciparum, interrupting malaria transmission. Indicated for radical cure of vivax/ovale malaria and falciparum gametocytocidal therapy.

Quinine Sulphate is a cinchona alkaloid schizontocidal antimalarial agent. It acts primarily on the asexual erythrocytic forms of all Plasmodium species by interfering with hemozoin synthesis and parasite digestion of hemoglobin. Indicated for uncomplicated and severe chloroquine-resistant Plasmodium falciparum malaria and nocturnal leg cramps (unlabeled, restricted due to toxicity).