TabletsClinical Overview
Artesunate, Sulfadoxine, and Pyrimethamine Combi Kit is a WHO-endorsed Artemisinin-based Combination Therapy (ACT). Artesunate acts rapidly to clear the bulk of malaria parasites by releasing reactive carbon-centered free radicals, while sulfadoxine (dihydropteroate synthase inhibitor) and pyrimethamine (dihydrofolate reductase inhibitor) provide synergistic long-acting anti-folate elimination of residual parasites. Indicated for the treatment of acute uncomplicated Plasmodium falciparum malaria.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally with food or milk over 3 consecutive days exactly as indicated on the combi-kit blister pack. Artesunate is taken on Days 1, 2, and 3; Sulfadoxine + Pyrimethamine is taken on Day 1 only as a single stat dose. Complete the full kit even if fever subsides completely.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Nausea, vomiting, abdominal pain, headache, dizziness, loss of appetite. Rare/Severe: Severe sulfonamide cutaneous reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis), agranulocytosis, and hemolytic anemia in G6PD deficiency.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Contraindicated in patients with known hypersensitivity to sulfonamides or pyrimethamine, severe renal or hepatic failure, and megaloblastic anemia due to folate deficiency. Caution in patients with G6PD deficiency. Ensure completion of all tablets in the combi-kit.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified pharmacist before initiating, modifying, or substituting any medication regimen.
Artesunate Injection 60 mg
Artesunate is a water-soluble hemisuccinate derivative of artemisinin and the WHO gold-standard first-line treatment for severe malaria. Its endoperoxide bridge is cleaved by intraparasitic heme-iron, generating free radicals that alkylate essential parasitic proteins and PfATP6, rapidly reducing parasite biomass within hours. Indicated parenterally for severe Plasmodium falciparum and vivax malaria, cerebral malaria, and complicated malarial infections.
Artesunate Injection 120mg
Artesunate is a water-soluble hemisuccinate derivative of artemisinin and the WHO gold-standard first-line treatment for severe malaria. Its endoperoxide bridge is cleaved by intraparasitic heme-iron, generating free radicals that alkylate essential parasitic proteins and PfATP6, rapidly reducing parasite biomass within hours. Indicated parenterally for severe Plasmodium falciparum and vivax malaria, cerebral malaria, and complicated malarial infections.