TabletsClinical Overview
Artemether and Lumefantrine is a premier oral Artemisinin-based Combination Therapy (ACT) on the WHO Model List of Essential Medicines. Artemether provides fast clearance of parasitemia through free radical production, while lumefantrine, a synthetic fluorene derivative, clears remaining parasites with a prolonged elimination half-life, preventing recrudescence and resistance development. Indicated for the treatment of acute uncomplicated Plasmodium falciparum and mixed malaria.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally with food or milk (or any high-fat meal), which enhances lumefantrine absorption sixteen-fold. Standard regimen comprises a 6-dose course over 3 days (at 0h, 8h, 24h, 36h, 48h, and 60h). If vomiting occurs within 1 hour of a dose, repeat the full dose immediately.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Headache, dizziness, anorexia, nausea, abdominal discomfort, cough, arthralgia. Rare/Severe: QT interval prolongation, severe hypersensitivity reactions, and angioedema.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Take strictly with fatty meals for clinical efficacy. Caution in patients with congenital QT prolongation, cardiac arrhythmias, or taking other QT-prolonging agents. Not indicated for severe/cerebral malaria or prophylaxis.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified pharmacist before initiating, modifying, or substituting any medication regimen.