InjectionClinical Overview
Drotaverine Hydrochloride Injection (40mg/2ml) is an injectable smooth muscle relaxant on the PMBI formulary. It selectively inhibits phosphodiesterase enzyme IV (PDE4) in smooth muscle cells, elevating intracellular cAMP and producing fast-acting spasmolysis in vascular, gastrointestinal, biliary, and urogenital smooth muscles. Indicated for acute renal colic, biliary colic, intestinal colic, and cervical spasm during active labor.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Administer by slow intravenous injection (over 3 to 5 minutes) or deep intramuscular injection. Adult dose: 40 to 80 mg IM or slow IV, repeated up to 3 times daily if needed. During slow IV administration, the patient must be in a supine position to avoid hypotension.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Transient hypotension, dizziness, nausea, injection site pain, flushing. Rare/Severe: Severe hypotension, collapse, cardiac arrhythmias, and anaphylaxis.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Inject slowly IV to prevent profound hypotension or collapse. Contraindicated in severe hepatic, renal, or cardiac insufficiency (severe AV block or heart failure).
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or gastrointestinal treatment recommendations. Always consult a registered gastroenterologist or qualified medical practitioner before initiating, altering, or discontinuing any gastrointestinal medication or digestive therapy.
Drotaverine Hydrochloride 80mg + Mefenamic Acid 250mg Tablets
Drotaverine Hydrochloride (80mg) and Mefenamic Acid (250mg) Tablets is a fixed-dose antispasmodic and non-steroidal anti-inflammatory (NSAID) combination. Drotaverine is an isoquinoline derivative that selectively inhibits phosphodiesterase-4 (PDE4), elevating intracellular cyclic AMP (cAMP) and causing rapid, powerful smooth muscle relaxation without anticholinergic side effects. Mefenamic acid inhibits cyclooxygenase (COX-1/COX-2), blocking pro-inflammatory and spasmogenic prostaglandin synthesis. Indicated for severe spasmodic dysmenorrhea, renal and ureteric colic, biliary colic, and acute spastic intestinal contractions.
Drotaverine Hydrochloride Tablets 40mg
Drotaverine Hydrochloride Tablets (40mg, 80mg) is an oral smooth muscle antispasmodic on the WHO Model List framework. As a selective PDE4 inhibitor, it relaxes visceral smooth muscle without anticholinergic activity, making it completely devoid of atropine-like adverse effects (no dry mouth, no urinary retention, no intraocular pressure elevation). Indicated for gastrointestinal spastic states (IBS, spastic colitis), biliary colic, cholecystitis, and ureteral colic.
Drotaverine 80mg + Aceclofenac 100mg Tablets
Drotaverine Hydrochloride (80mg) and Aceclofenac (100mg) Tablets combines a selective phosphodiesterase-4 (PDE4) inhibitor smooth muscle relaxant with a COX-2 preferential NSAID. Drotaverine elevates cyclic AMP in visceral smooth muscle to abolish spastic contractions, while aceclofenac inhibits prostaglandin synthesis, eliminating inflammation and pain. Indicated for severe spasmodic dysmenorrhea, biliary colic, renal/ureteric colic, and spasmodic abdominal pain.
Drotaverine Hydrochloride Tablets 80 mg
Drotaverine Hydrochloride Tablets (40mg, 80mg) is an oral smooth muscle antispasmodic on the WHO Model List framework. As a selective PDE4 inhibitor, it relaxes visceral smooth muscle without anticholinergic activity, making it completely devoid of atropine-like adverse effects (no dry mouth, no urinary retention, no intraocular pressure elevation). Indicated for gastrointestinal spastic states (IBS, spastic colitis), biliary colic, cholecystitis, and ureteral colic.