Drotaverine

Drotaverine Hydrochloride (80mg) and Mefenamic Acid (250mg) Tablets is a fixed-dose antispasmodic and non-steroidal anti-inflammatory (NSAID) combination. Drotaverine is an isoquinoline derivative that selectively inhibits phosphodiesterase-4 (PDE4), elevating intracellular cyclic AMP (cAMP) and causing rapid, powerful smooth muscle relaxation without anticholinergic side effects. Mefenamic acid inhibits cyclooxygenase (COX-1/COX-2), blocking pro-inflammatory and spasmogenic prostaglandin synthesis. Indicated for severe spasmodic dysmenorrhea, renal and ureteric colic, biliary colic, and acute spastic intestinal contractions.

Drotaverine Hydrochloride Tablets (40mg, 80mg) is an oral smooth muscle antispasmodic on the WHO Model List framework. As a selective PDE4 inhibitor, it relaxes visceral smooth muscle without anticholinergic activity, making it completely devoid of atropine-like adverse effects (no dry mouth, no urinary retention, no intraocular pressure elevation). Indicated for gastrointestinal spastic states (IBS, spastic colitis), biliary colic, cholecystitis, and ureteral colic.

Drotaverine Hydrochloride (80mg) and Aceclofenac (100mg) Tablets combines a selective phosphodiesterase-4 (PDE4) inhibitor smooth muscle relaxant with a COX-2 preferential NSAID. Drotaverine elevates cyclic AMP in visceral smooth muscle to abolish spastic contractions, while aceclofenac inhibits prostaglandin synthesis, eliminating inflammation and pain. Indicated for severe spasmodic dysmenorrhea, biliary colic, renal/ureteric colic, and spasmodic abdominal pain.

Drotaverine Hydrochloride Tablets (40mg, 80mg) is an oral smooth muscle antispasmodic on the WHO Model List framework. As a selective PDE4 inhibitor, it relaxes visceral smooth muscle without anticholinergic activity, making it completely devoid of atropine-like adverse effects (no dry mouth, no urinary retention, no intraocular pressure elevation). Indicated for gastrointestinal spastic states (IBS, spastic colitis), biliary colic, cholecystitis, and ureteral colic.

Drotaverine Hydrochloride Injection (40mg/2ml) is an injectable smooth muscle relaxant on the PMBI formulary. It selectively inhibits phosphodiesterase enzyme IV (PDE4) in smooth muscle cells, elevating intracellular cAMP and producing fast-acting spasmolysis in vascular, gastrointestinal, biliary, and urogenital smooth muscles. Indicated for acute renal colic, biliary colic, intestinal colic, and cervical spasm during active labor.