Topical Corticosteroids & Anti-Itch

Clobetasol Propionate (0.05% w/w) is an ultra-high potency (Class I) topical synthetic corticosteroid on the WHO Model List of Essential Medicines. It binds to intracellular glucocorticoid receptors, down-regulating inflammatory cytokines (IL-1, IL-2, TNF-alpha) and inducing lipocortins to block phospholipase A2 and arachidonic acid cascade products. Indicated for short-term management of moderate-to-severe plaque psoriasis, recalcitrant dermatoses, lichen planus, and severe discoid lupus erythematosus.

Betamethasone Valerate / Dipropionate is a potent topical corticosteroid on the WHO Model List of Essential Medicines. It suppresses cutaneous inflammatory edema, erythema, and pruritus in eczema, psoriasis, and severe contact dermatitis. Often formulated in combination with Fusidic Acid, Gentamicin, or Miconazole to treat secondarily infected dermatoses.

Betamethasone Valerate / Dipropionate is a potent topical corticosteroid on the WHO Model List of Essential Medicines. It suppresses cutaneous inflammatory edema, erythema, and pruritus in eczema, psoriasis, and severe contact dermatitis. Often formulated in combination with Fusidic Acid, Gentamicin, or Miconazole to treat secondarily infected dermatoses.

Clobetasol Propionate (0.05%) combined with antibacterial (Gentamicin/Neomycin) and/or antifungal (Miconazole) agents. Delivers rapid anti-inflammatory and anti-pruritic relief while providing broad-spectrum coverage against secondary bacterial and candidal/dermatophyte infections in steroid-responsive dermatoses. Indicated for infected inflammatory dermatoses, infected eczema, and severe intertrigo.

Mometasone Furoate (0.1% w/w cream/ointment) is a high-potency (Class II) synthetic topical corticosteroid on the WHO Model List of Essential Medicines. It features a high therapeutic index, providing robust anti-inflammatory and anti-pruritic activity with significantly lower systemic absorption and cutaneous atrophogenic potential than older fluorinated steroids. Indicated for relief of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses, including atopic dermatitis and psoriasis.

Betamethasone Valerate / Dipropionate is a potent topical corticosteroid on the WHO Model List of Essential Medicines. It suppresses cutaneous inflammatory edema, erythema, and pruritus in eczema, psoriasis, and severe contact dermatitis. Often formulated in combination with Fusidic Acid, Gentamicin, or Miconazole to treat secondarily infected dermatoses.

Apremilast is an oral small-molecule phosphodiesterase 4 (PDE4) inhibitor on the WHO Model List of Essential Medicines. By inhibiting PDE4, it elevates intracellular cyclic adenosine monophosphate (cAMP), down-regulating pro-inflammatory cytokine expression (TNF-alpha, IL-17, IL-23) while up-regulating anti-inflammatory IL-10. Indicated for moderate-to-severe plaque psoriasis in adults who are candidates for phototherapy or systemic therapy, and active psoriatic arthritis.

Apremilast is an oral small-molecule phosphodiesterase 4 (PDE4) inhibitor on the WHO Model List of Essential Medicines. By inhibiting PDE4, it elevates intracellular cyclic adenosine monophosphate (cAMP), down-regulating pro-inflammatory cytokine expression (TNF-alpha, IL-17, IL-23) while up-regulating anti-inflammatory IL-10. Indicated for moderate-to-severe plaque psoriasis in adults who are candidates for phototherapy or systemic therapy, and active psoriatic arthritis.

Apremilast is an oral small-molecule phosphodiesterase 4 (PDE4) inhibitor on the WHO Model List of Essential Medicines. By inhibiting PDE4, it elevates intracellular cyclic adenosine monophosphate (cAMP), down-regulating pro-inflammatory cytokine expression (TNF-alpha, IL-17, IL-23) while up-regulating anti-inflammatory IL-10. Indicated for moderate-to-severe plaque psoriasis in adults who are candidates for phototherapy or systemic therapy, and active psoriatic arthritis.

Betamethasone Valerate / Dipropionate is a potent topical corticosteroid on the WHO Model List of Essential Medicines. It suppresses cutaneous inflammatory edema, erythema, and pruritus in eczema, psoriasis, and severe contact dermatitis. Often formulated in combination with Fusidic Acid, Gentamicin, or Miconazole to treat secondarily infected dermatoses.

Clobetasol Propionate (0.05%) combined with antibacterial (Gentamicin/Neomycin) and/or antifungal (Miconazole) agents. Delivers rapid anti-inflammatory and anti-pruritic relief while providing broad-spectrum coverage against secondary bacterial and candidal/dermatophyte infections in steroid-responsive dermatoses. Indicated for infected inflammatory dermatoses, infected eczema, and severe intertrigo.

Clobetasol Propionate (0.05%) combined with antibacterial (Gentamicin/Neomycin) and/or antifungal (Miconazole) agents. Delivers rapid anti-inflammatory and anti-pruritic relief while providing broad-spectrum coverage against secondary bacterial and candidal/dermatophyte infections in steroid-responsive dermatoses. Indicated for infected inflammatory dermatoses, infected eczema, and severe intertrigo.

Clobetasol Propionate (0.05%) combined with antibacterial (Gentamicin/Neomycin) and/or antifungal (Miconazole) agents. Delivers rapid anti-inflammatory and anti-pruritic relief while providing broad-spectrum coverage against secondary bacterial and candidal/dermatophyte infections in steroid-responsive dermatoses. Indicated for infected inflammatory dermatoses, infected eczema, and severe intertrigo.

Clobetasol Propionate (0.05%) combined with antibacterial (Gentamicin/Neomycin) and/or antifungal (Miconazole) agents. Delivers rapid anti-inflammatory and anti-pruritic relief while providing broad-spectrum coverage against secondary bacterial and candidal/dermatophyte infections in steroid-responsive dermatoses. Indicated for infected inflammatory dermatoses, infected eczema, and severe intertrigo.

Betamethasone Valerate / Dipropionate is a potent topical corticosteroid on the WHO Model List of Essential Medicines. It suppresses cutaneous inflammatory edema, erythema, and pruritus in eczema, psoriasis, and severe contact dermatitis. Often formulated in combination with Fusidic Acid, Gentamicin, or Miconazole to treat secondarily infected dermatoses.

Betamethasone Valerate / Dipropionate is a potent topical corticosteroid on the WHO Model List of Essential Medicines. It suppresses cutaneous inflammatory edema, erythema, and pruritus in eczema, psoriasis, and severe contact dermatitis. Often formulated in combination with Fusidic Acid, Gentamicin, or Miconazole to treat secondarily infected dermatoses.

Tacrolimus (0.03%, 0.1% ointment) is a topical calcineurin inhibitor (TCI) and non-steroidal immunosuppressant on the WHO Model List of Essential Medicines. It binds to intracellular immunophilin FKBP-12, forming a complex that inhibits calcineurin phosphatase, preventing dephosphorylation of NF-AT and blocking transcription of pro-inflammatory cytokines (IL-2, IL-3, IL-4, IFN-gamma) in T-lymphocytes. Unlike steroids, it does not cause skin atrophy, telangiectasia, or collagen breakdown. Indicated for moderate-to-severe atopic dermatitis (eczema) in patients not adequately responsive to or intolerant of conventional topical therapies, especially on the face, neck, and flexures.

Halobetasol Propionate (0.05% w/w) is an ultra-high potency (Class I) fluorinated topical corticosteroid. It produces intense vasoconstriction, suppression of immune cell migration, and potent anti-inflammatory action in severe hyperkeratotic and inflammatory skin conditions. Indicated for plaque psoriasis and severe steroid-responsive dermatoses.

Clobetasol Propionate (0.05% w/w) is an ultra-high potency (Class I) topical synthetic corticosteroid on the WHO Model List of Essential Medicines. It binds to intracellular glucocorticoid receptors, down-regulating inflammatory cytokines (IL-1, IL-2, TNF-alpha) and inducing lipocortins to block phospholipase A2 and arachidonic acid cascade products. Indicated for short-term management of moderate-to-severe plaque psoriasis, recalcitrant dermatoses, lichen planus, and severe discoid lupus erythematosus.

Nadifloxacin (1% w/w cream) is a synthetic broad-spectrum fluoroquinolone bactericidal antibacterial agent for topical dermatological use. It inhibits bacterial DNA gyrase (topoisomerase II), blocking bacterial DNA replication against Cutibacterium acnes, Staphylococcus epidermidis, and methicillin-resistant S. aureus (MRSA). Indicated for acne vulgaris, folliculitis, and superficial bacterial skin infections.

Hydrocortisone Acetate (1% w/w) is a low-potency (Class VII) topical corticosteroid on the WHO Model List of Essential Medicines. It represents the safest topical steroid for sensitive skin areas (face, intertriginous skin folds, groin) and pediatric patients, providing anti-inflammatory, anti-pruritic, and mild vasoconstrictive actions with minimal risk of skin thinning or systemic absorption. Indicated for mild eczema, facial dermatitis, intertrigo, insect bites, and anogenital pruritus.

Hydrocortisone Acetate (1% w/w) is a low-potency (Class VII) topical corticosteroid on the WHO Model List of Essential Medicines. It represents the safest topical steroid for sensitive skin areas (face, intertriginous skin folds, groin) and pediatric patients, providing anti-inflammatory, anti-pruritic, and mild vasoconstrictive actions with minimal risk of skin thinning or systemic absorption. Indicated for mild eczema, facial dermatitis, intertrigo, insect bites, and anogenital pruritus.

Hydrocortisone Acetate (1% w/w) is a low-potency (Class VII) topical corticosteroid on the WHO Model List of Essential Medicines. It represents the safest topical steroid for sensitive skin areas (face, intertriginous skin folds, groin) and pediatric patients, providing anti-inflammatory, anti-pruritic, and mild vasoconstrictive actions with minimal risk of skin thinning or systemic absorption. Indicated for mild eczema, facial dermatitis, intertrigo, insect bites, and anogenital pruritus.

Nadifloxacin (1% w/w cream) is a synthetic broad-spectrum fluoroquinolone bactericidal antibacterial agent for topical dermatological use. It inhibits bacterial DNA gyrase (topoisomerase II), blocking bacterial DNA replication against Cutibacterium acnes, Staphylococcus epidermidis, and methicillin-resistant S. aureus (MRSA). Indicated for acne vulgaris, folliculitis, and superficial bacterial skin infections.

Tofacitinib (2% w/w ointment) is a topical Janus kinase (JAK1/JAK3) inhibitor. It blocks intracellular JAK-STAT signaling pathways for multiple key inflammatory cytokines (IL-4, IL-13, IL-22, IL-31), rapidly reducing itch and clearing epidermal inflammation in inflammatory skin diseases without causing steroid-induced skin atrophy. Indicated for atopic dermatitis, alopecia areata, and plaque psoriasis.

Fluocinolone Acetonide / Fluocinonide is an intermediate-to-high potency fluorinated topical corticosteroid. It suppresses cutaneous inflammation and capillary permeability. Indicated for atopic dermatitis, severe contact dermatitis, and lichenified eczema.

Halobetasol Propionate (0.05% w/w) is an ultra-high potency (Class I) fluorinated topical corticosteroid. It produces intense vasoconstriction, suppression of immune cell migration, and potent anti-inflammatory action in severe hyperkeratotic and inflammatory skin conditions. Indicated for plaque psoriasis and severe steroid-responsive dermatoses.