Clinical Overview
Clobetasol Propionate (0.05% w/w) is an ultra-high potency (Class I) topical synthetic corticosteroid on the WHO Model List of Essential Medicines. It binds to intracellular glucocorticoid receptors, down-regulating inflammatory cytokines (IL-1, IL-2, TNF-alpha) and inducing lipocortins to block phospholipase A2 and arachidonic acid cascade products. Indicated for short-term management of moderate-to-severe plaque psoriasis, recalcitrant dermatoses, lichen planus, and severe discoid lupus erythematosus.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Apply a thin layer sparingly to affected skin areas once or twice daily. Rub in gently. Maximum dose: 50 g per week. Treatment must not exceed 2 to 4 consecutive weeks.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Burning, stinging, localized pruritus, skin dryness. Rare/Severe: HPA axis suppression, cutaneous atrophy, striae rubrae, telangiectasia, steroid acne, and perioral dermatitis.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Ultra-high potency: strictly avoid face, neck, axillae, and groin. Do not use with occlusive bandages. Discontinue once controlled; taper gradually to prevent rebound flare.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered dermatologist or qualified medical practitioner before initiating, altering, or substituting any topical or systemic dermatological treatment.