TabletsClinical Overview
Apremilast is an oral small-molecule phosphodiesterase 4 (PDE4) inhibitor on the WHO Model List of Essential Medicines. By inhibiting PDE4, it elevates intracellular cyclic adenosine monophosphate (cAMP), down-regulating pro-inflammatory cytokine expression (TNF-alpha, IL-17, IL-23) while up-regulating anti-inflammatory IL-10. Indicated for moderate-to-severe plaque psoriasis in adults who are candidates for phototherapy or systemic therapy, and active psoriatic arthritis.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally with water, with or without meals, twice daily following the initial 5-day dose-titration schedule (10 mg to 30 mg). Swallow tablets whole; do not crush or chew. Titration minimizes gastrointestinal adverse effects.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Diarrhea (usually within first 2 weeks, transient), nausea, upper respiratory tract infection, tension headache, weight loss. Rare/Severe: Severe depression and suicidal ideation, severe prolonged diarrhea, and hypersensitivity.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Monitor for new or worsening depression and suicidal thoughts. Monitor body weight regularly; evaluate unexplained significant weight loss. Reduce dose to 30 mg once daily in severe renal impairment (CrCl < 30 mL/min).
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered dermatologist or qualified medical practitioner before initiating, altering, or substituting any topical or systemic dermatological treatment.
Calamine Lotion
Calamine lotion (Zinc Oxide and Ferric Oxide with Aloe Vera and Light Liquid Paraffin) is a classic topical soothing astringent and antipruritic on the WHO Model List of Essential Medicines. It evaporates to cool the skin, while zinc oxide provides mild antiseptic and protective barrier coverage. Indicated for symptomatic relief of itching, insect bites, sunburn, chickenpox rash, poison ivy, and prickly heat.
Clobetasol Propionate Cream 0.05 %
Clobetasol Propionate (0.05% w/w) is an ultra-high potency (Class I) topical synthetic corticosteroid on the WHO Model List of Essential Medicines. It binds to intracellular glucocorticoid receptors, down-regulating inflammatory cytokines (IL-1, IL-2, TNF-alpha) and inducing lipocortins to block phospholipase A2 and arachidonic acid cascade products. Indicated for short-term management of moderate-to-severe plaque psoriasis, recalcitrant dermatoses, lichen planus, and severe discoid lupus erythematosus.
Vitamins A, C, D, E & B-Complex with Minerals Syrup
Vitamin B-Complex Formulations (Tablets, Capsules with Zinc, Syrup, and Injection) is a balanced formulation of essential B-group vitamins (B1 Thiamine, B2 Riboflavin, B3 Niacinamide, B5 Calcium Pantothenate, B6 Pyridoxine, B9 Folic Acid, B12 Cobalamin) on the WHO Model List of Essential Medicines. B-vitamins act as critical water-soluble coenzymes in cellular Krebs cycle energy production, carbohydrate and lipid metabolism, erythropoiesis, and myelin integrity. Indicated for prevention and treatment of generalized B-complex deficiencies, aphthous stomatitis/glossitis/angular cheilitis, convalescence, chronic debilitating illness, and nutritional maintenance during prolonged antibiotic therapy.
Vitamin E Softgel Capsules 400 mg
Vitamin E Soft Gel Capsules (200mg, 400mg, 600mg) is an oral fat-soluble antioxidant (d-alpha-tocopheryl acetate) on the WHO Model List framework. It integrates into phospholipid cell membranes, where it traps peroxyl free radicals and halts the propagation of lipid peroxidation chain reactions, protecting polyunsaturated fatty acids in membranes, red blood cells, and vascular endothelial cells from oxidative injury. Indicated for vitamin E deficiency, supportive management of non-alcoholic fatty liver disease (NASH), peripheral neuropathy in abetalipoproteinemia, and adjuvant skin/hair health.