TabletsClinical Overview
Tramadol Hydrochloride (50mg immediate-release) and Diclofenac Sodium (75mg sustained-release) Tablets combines a centrally acting dual-mechanism opioid with a potent peripheral non-steroidal anti-inflammatory drug (NSAID). Tramadol dampens central pain transmission via mu-opioid activation and monoaminergic reuptake inhibition; diclofenac blocks peripheral COX-1 and COX-2 enzymes to eliminate tissue inflammation and prostaglandin-mediated sensitization of nociceptors. Indicated for severe acute and chronic musculoskeletal pain, post-surgical orthopedic pain, and severe osteoarthritic/rheumatoid joint destruction.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally 1 tablet once or twice daily after a full meal with a large glass of water. Swallow whole; do NOT crush, split, or chew the sustained-release tablet.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Nausea, epigastric distress, dizziness, drowsiness, constipation, headache, dyspepsia. Rare/Severe: Gastrointestinal ulceration and hemorrhage, seizures, respiratory depression, cardiovascular thrombotic events (myocardial infarction/stroke), and acute kidney injury.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Schedule H1 Prescription Analgesic: Black Box Warning for GI bleeding, ulceration, and CV thrombotic risks from diclofenac, along with opioid dependence and seizure risk from tramadol. Contraindicated in active peptic ulcer disease, coronary bypass surgery (CABG), severe heart failure, and epilepsy. Avoid alcohol.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or analgesic treatment guidance. Always consult a registered physician or orthopedic specialist before taking pain relievers, anti-inflammatory medications, or anti-arthritic therapies.
Chlorzoxazone 500mg + Diclofenac 50mg + Paracetamol 325mg Tablets
Paracetamol (325mg/500mg) and Chlorzoxazone (250mg) Tablets is a centrally acting skeletal muscle relaxant and analgesic combination. Chlorzoxazone inhibits multi-synaptic reflex arcs in the spinal cord and subcortical areas of the brain, relieving painful skeletal muscle spasms. Paracetamol acts centrally to alleviate associated pain and discomfort. Indicated for acute, painful musculoskeletal conditions, muscle spasms, lumbago, torticollis, and strain/sprain trauma.
Diclofenac Gel 1.16% (Diclofenac Diethylamine)
Diclofenac Gel 1.16% (Diclofenac Diethylamine) is an evidence-based dermatological formulation. It acts by delivering targeted active therapeutic ingredients to cutaneous lesions to relieve skin pathology, restore barrier integrity, and manage dermatoses.
Serratiopeptidase 10mg + Diclofenac Sodium 50mg Tablets
Diclofenac Sodium/Potassium Tablets (50mg Gastro-Resistant, 75mg/100mg Prolonged Release) is an oral phenylacetic acid non-steroidal anti-inflammatory drug (NSAID) on the WHO Model List of Essential Medicines. It potently inhibits both cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes, halting prostaglandin synthesis, and also reduces intracellular concentrations of free arachidonic acid in leukocytes. Potassium salt provides rapid dissolution and quick pain relief; sodium prolonged-release provides steady 24-hour therapeutic coverage. Indicated for relief of pain and inflammation in osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute musculoskeletal disorders, and acute migraine attacks.
Diclofenac Sodium Prolonged Release Tablets 100 mg
Diclofenac Sodium/Potassium Tablets (50mg Gastro-Resistant, 75mg/100mg Prolonged Release) is an oral phenylacetic acid non-steroidal anti-inflammatory drug (NSAID) on the WHO Model List of Essential Medicines. It potently inhibits both cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes, halting prostaglandin synthesis, and also reduces intracellular concentrations of free arachidonic acid in leukocytes. Potassium salt provides rapid dissolution and quick pain relief; sodium prolonged-release provides steady 24-hour therapeutic coverage. Indicated for relief of pain and inflammation in osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute musculoskeletal disorders, and acute migraine attacks.