TabletsMRP Under Process
Official PMBI MRP is being updated for catalog code 2520.
Locate Jan Aushadhi KendraClinical Overview
Endothelin Receptor Antagonist (ERA) on the WHO Model List of Essential Medicines. Endothelin-1 is a potent endogenous vasoconstrictor and vascular smooth muscle mitogen; ERAs selectively or dualistically block endothelin receptors (ETA and ETB) on pulmonary vascular smooth muscle, reversing pulmonary vasoconstriction, inhibiting vascular remodeling, and reducing pulmonary vascular resistance. Indicated for Pulmonary Arterial Hypertension (PAH, WHO Group 1) to improve exercise capacity and delay clinical worsening.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally once daily (or twice daily for bosentan) with a glass of water, with or without food. Swallow tablets whole. Strict monthly liver function tests and pregnancy tests are mandatory.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Peripheral edema, fluid retention, nasal congestion, headache, flushing, anemia. Rare/Severe: Boxed warnings: Major birth defects/fetal toxicity; severe hepatotoxicity/liver failure (especially with bosentan), and severe decrease in hemoglobin/hematocrit.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Black box warnings: (1) Severe teratogenicity/embryo-fetal toxicity (monthly pregnancy testing mandatory in females of childbearing potential); (2) Hepatotoxicity (monthly liver enzyme monitoring mandatory for bosentan). Monitor hemoglobin/hematocrit periodically.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified cardiologist/pharmacist before initiating, altering, or substituting any cardiovascular medication.
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Endothelin Receptor Antagonist (ERA) on the WHO Model List of Essential Medicines. Endothelin-1 is a potent endogenous vasoconstrictor and vascular smooth muscle mitogen; ERAs selectively or dualistically block endothelin receptors (ETA and ETB) on pulmonary vascular smooth muscle, reversing pulmonary vasoconstriction, inhibiting vascular remodeling, and reducing pulmonary vascular resistance. Indicated for Pulmonary Arterial Hypertension (PAH, WHO Group 1) to improve exercise capacity and delay clinical worsening.
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Endothelin Receptor Antagonist (ERA) on the WHO Model List of Essential Medicines. Endothelin-1 is a potent endogenous vasoconstrictor and vascular smooth muscle mitogen; ERAs selectively or dualistically block endothelin receptors (ETA and ETB) on pulmonary vascular smooth muscle, reversing pulmonary vasoconstriction, inhibiting vascular remodeling, and reducing pulmonary vascular resistance. Indicated for Pulmonary Arterial Hypertension (PAH, WHO Group 1) to improve exercise capacity and delay clinical worsening.