Ambrisentan
Active pharmaceutical substance formulated in Jan Aushadhi generic products for Cardiac & Hypertension treatment.
🧴 Clinical Application
Take orally once daily (or twice daily for bosentan) with a glass of water, with or without food. Swallow tablets whole. Strict monthly liver function tests and pregnancy tests are mandatory.
⚠️ Side Effects
Common: Peripheral edema, fluid retention, nasal congestion, headache, flushing, anemia. Rare/Severe: Boxed warnings: Major birth defects/fetal toxicity; severe hepatotoxicity/liver failure (especially with bosentan), and severe decrease in hemoglobin/hematocrit.
🛡️ Safety Warnings
Black box warnings: (1) Severe teratogenicity/embryo-fetal toxicity (monthly pregnancy testing mandatory in females of childbearing potential); (2) Hepatotoxicity (monthly liver enzyme monitoring mandatory for bosentan). Monitor hemoglobin/hematocrit periodically.
Jan Aushadhi Products containing Ambrisentan
Found 3 generic formulation(s) containing this active ingredient.
Ambrisentan Tablets 10mg
Endothelin Receptor Antagonist (ERA) on the WHO Model List of Essential Medicines. Endothelin-1 is a potent endogenous vasoconstrictor and vascular smooth muscle mitogen; ERAs selectively or dualistically block endothelin receptors (ETA and ETB) on pulmonary vascular smooth muscle, reversing pulmonary vasoconstriction, inhibiting vascular remodeling, and reducing pulmonary vascular resistance. Indicated for Pulmonary Arterial Hypertension (PAH, WHO Group 1) to improve exercise capacity and delay clinical worsening.
Ambrisentan Tablets 5mg
Endothelin Receptor Antagonist (ERA) on the WHO Model List of Essential Medicines. Endothelin-1 is a potent endogenous vasoconstrictor and vascular smooth muscle mitogen; ERAs selectively or dualistically block endothelin receptors (ETA and ETB) on pulmonary vascular smooth muscle, reversing pulmonary vasoconstriction, inhibiting vascular remodeling, and reducing pulmonary vascular resistance. Indicated for Pulmonary Arterial Hypertension (PAH, WHO Group 1) to improve exercise capacity and delay clinical worsening.
Combipack of Ambrisentan 5mg + Tadalafil 20mg Tablets
Endothelin Receptor Antagonist (ERA) on the WHO Model List of Essential Medicines. Endothelin-1 is a potent endogenous vasoconstrictor and vascular smooth muscle mitogen; ERAs selectively or dualistically block endothelin receptors (ETA and ETB) on pulmonary vascular smooth muscle, reversing pulmonary vasoconstriction, inhibiting vascular remodeling, and reducing pulmonary vascular resistance. Indicated for Pulmonary Arterial Hypertension (PAH, WHO Group 1) to improve exercise capacity and delay clinical worsening.
Brand Equivalents & Price Comparison
Compare Jan Aushadhi generic prices against popular commercial brands for Ambrisentan.
| Generic Formulation | Pack Size | Jan Aushadhi Price | Commercial Brand Equivalents | Avg. Commercial Price | Savings |
|---|---|---|---|---|---|
| Ambrisentan Tablets 10mg | 10's | Under Process | N/A | N/A | N/A |
| Ambrisentan Tablets 5mg | 10's | Under Process | N/A | N/A | N/A |
| Combipack of Ambrisentan 5mg + Tadalafil 20mg Tablets | 20's in Combikit | Under Process | N/A | N/A | N/A |
Frequently Asked Questions (FAQ)
Get answers to common queries about Ambrisentan generics.