CapsulesClinical Overview
Esomeprazole Magnesium (40mg enteric-coated) and Itopride Hydrochloride (150mg sustained-release) combines an S-isomer PPI with a dual D2-antagonist/acetylcholinesterase-inhibiting prokinetic. Provides potent, round-the-clock acid suppression along with enhanced physiological acetylcholine-mediated peristalsis without cardiac HERG channel interactions. Indicated for erosive GERD and functional dyspepsia.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally once daily before breakfast with water. Swallow whole without chewing.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Diarrhea, headache, abdominal pain, flatulence, mild nausea. Rare/Severe: Hypersensitivity reactions, leukopenia, and hepatic enzyme elevation.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Contraindicated in mechanical GI obstruction or acute bleeding. Use with caution in hepatic impairment.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or gastrointestinal treatment recommendations. Always consult a registered gastroenterologist or qualified medical practitioner before initiating, altering, or discontinuing any gastrointestinal medication or digestive therapy.
Esomeprazole 40mg (Enteric-Coated) + Domperidone 30mg (Sustained Release) Capsules
Esomeprazole (40mg enteric-coated) and Domperidone (30mg sustained-release) combines the pure S-enantiomer of omeprazole with an antiemetic prokinetic. Esomeprazole provides superior bioavailability and acid suppression compared to racemic omeprazole by undergoing lower first-pass hepatic metabolism via CYP2C19. Domperidone provides dopamine D2 receptor antagonism, enhancing lower esophageal sphincter tone and gastroduodenal transit. Indicated for erosive reflux esophagitis, GERD poorly responsive to standard acid suppression, and diabetic gastroparesis with nausea.
Esomeprazole 40mg (Enteric-coated) + Levosulpiride 75mg (Sustained release) Capsules
Esomeprazole (40mg enteric-coated) and Levosulpiride (75mg sustained-release) combines an S-isomer proton pump inhibitor with a central/peripheral prokinetic benzamide. Esomeprazole exerts long-lasting suppression of basal and meal-stimulated gastric acid secretion. Levosulpiride selectively blocks enteric D2 receptors and stimulates 5-HT4 receptors, dramatically improving gastric accommodation and antral motility. Indicated for severe GERD, refractory non-ulcer dyspepsia, and gastroparesis.
Esomeprazole Tablets 40 mg
Omeprazole Gastro-Resistant Capsules (20mg) is a prototypical proton pump inhibitor on the WHO Model List of Essential Medicines. It enters parietal cell canaliculi as a prodrug where acidic pH converts it to a tetracyclic sulfenamide that permanently inactivates H+/K+-ATPase pumps. Indicated for duodenal ulcers, benign gastric ulcers, reflux esophagitis, maintenance therapy of healed erosive esophagitis, and H. pylori eradication (as part of triple therapy).
Itopride Tablets 50 mg
Itopride Hydrochloride Tablets (50mg) is a prokinetic gastroprokinetic agent on the PMBI formulary. It exerts a dual mechanism of action: competitive antagonism of dopamine D2 receptors and inhibition of acetylcholinesterase (AChE), preventing acetylcholine degradation in the myenteric plexus. This enhances upper GI motility, improves gastric accommodation, and accelerates emptying without crossing into the brain or affecting cardiac HERG channels. Indicated for functional dyspepsia, postprandial fullness, early satiety, epigastric bloating, and heartburn.