TabletsClinical Overview
Paracetamol (162.5mg/325mg) and Tramadol Hydrochloride (18.75mg/37.5mg) Tablets is a synergistic, multi-mechanistic analgesic combination on the WHO Model List framework for moderate-to-severe pain. Tramadol acts as a weak mu-opioid receptor agonist while simultaneously inhibiting the reuptake of norepinephrine and serotonin (5-HT) in the descending spinal pain inhibitory pathways. Paracetamol acts centrally to inhibit prostaglandin synthesis and activate descending serotonergic pathways. Combining them produces additive analgesia at lower individual doses with faster onset (paracetamol ~30 min) and extended duration (tramadol 6-8 hours). Indicated for management of moderate-to-severe acute pain, postoperative pain, acute musculoskeletal trauma, and severe osteoarthritis flares.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally 1 to 2 tablets every 4 to 6 hours as needed for severe pain with a glass of water. Maximum dose: do NOT exceed 8 tablets daily (300 mg tramadol / 2600 mg paracetamol). Swallow whole; do not crush or chew. Take with food if nausea occurs. Strictly avoid alcohol.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Nausea, dizziness, somnolence, constipation, sweating, headache, dry mouth, vomiting. Rare/Severe: Respiratory depression, seizures (lowers convulsive threshold), serotonin syndrome (with serotonergic drugs), physical dependence/addiction, and acute hepatotoxicity (paracetamol overdose).
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Schedule H1 Prescription Opioid: Risk of physical dependence, tolerance, and misuse. Lowers seizure threshold; contraindicated in patients with epilepsy or taking SSRIs/SNRIs/TCAs. Strictly avoid alcohol (risk of fatal respiratory depression). Contraindicated in severe hepatic or renal impairment.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or analgesic treatment guidance. Always consult a registered physician or orthopedic specialist before taking pain relievers, anti-inflammatory medications, or anti-arthritic therapies.
Aceclofenac 100mg + Paracetamol 325mg Tablets
Paracetamol / Acetaminophen (Tablets 500mg, 650mg, 1000mg; Oral Suspension 120mg, 125mg, 250mg per 5ml; Drops 100mg/ml) is a first-line non-opioid analgesic and antipyretic on the WHO Model List of Essential Medicines. It selectively inhibits central prostaglandin synthesis through peroxidase-dependent inhibition of COX enzymes in the brain and spinal cord, activates descending serotonergic inhibitory pathways, and resets the hypothalamic thermoregulatory center to reduce fever through cutaneous vasodilation and sweating. Unlike NSAIDs, it does NOT inhibit peripheral cyclooxygenase, causing zero gastric mucosal ulceration, platelet dysfunction, or renal vasoconstriction. Indicated as first-line therapy for mild-to-moderate pain (headache, toothache, dysmenorrhea, osteoarthritis) and fever of diverse etiologies.
Chlorzoxazone 500mg + Diclofenac 50mg + Paracetamol 325mg Tablets
Paracetamol (325mg/500mg) and Chlorzoxazone (250mg) Tablets is a centrally acting skeletal muscle relaxant and analgesic combination. Chlorzoxazone inhibits multi-synaptic reflex arcs in the spinal cord and subcortical areas of the brain, relieving painful skeletal muscle spasms. Paracetamol acts centrally to alleviate associated pain and discomfort. Indicated for acute, painful musculoskeletal conditions, muscle spasms, lumbago, torticollis, and strain/sprain trauma.
Ibuprofen 400mg + Paracetamol 325mg Tablets
Paracetamol / Acetaminophen (Tablets 500mg, 650mg, 1000mg; Oral Suspension 120mg, 125mg, 250mg per 5ml; Drops 100mg/ml) is a first-line non-opioid analgesic and antipyretic on the WHO Model List of Essential Medicines. It selectively inhibits central prostaglandin synthesis through peroxidase-dependent inhibition of COX enzymes in the brain and spinal cord, activates descending serotonergic inhibitory pathways, and resets the hypothalamic thermoregulatory center to reduce fever through cutaneous vasodilation and sweating. Unlike NSAIDs, it does NOT inhibit peripheral cyclooxygenase, causing zero gastric mucosal ulceration, platelet dysfunction, or renal vasoconstriction. Indicated as first-line therapy for mild-to-moderate pain (headache, toothache, dysmenorrhea, osteoarthritis) and fever of diverse etiologies.
Nimesulide 100mg + Paracetamol 325mg Tablets
Paracetamol / Acetaminophen (Tablets 500mg, 650mg, 1000mg; Oral Suspension 120mg, 125mg, 250mg per 5ml; Drops 100mg/ml) is a first-line non-opioid analgesic and antipyretic on the WHO Model List of Essential Medicines. It selectively inhibits central prostaglandin synthesis through peroxidase-dependent inhibition of COX enzymes in the brain and spinal cord, activates descending serotonergic inhibitory pathways, and resets the hypothalamic thermoregulatory center to reduce fever through cutaneous vasodilation and sweating. Unlike NSAIDs, it does NOT inhibit peripheral cyclooxygenase, causing zero gastric mucosal ulceration, platelet dysfunction, or renal vasoconstriction. Indicated as first-line therapy for mild-to-moderate pain (headache, toothache, dysmenorrhea, osteoarthritis) and fever of diverse etiologies.