CapsulesClinical Overview
Aceclofenac (200mg sustained-release) and Rabeprazole Sodium (20mg enteric-coated) Capsules is a gastro-protective NSAID combination. Aceclofenac is a phenylacetic acid NSAID that selectively inhibits COX-2 over COX-1, relieving joint pain and inflammation in osteoarthritis and ankylosing spondylitis. Rabeprazole is a fast-acting proton pump inhibitor that suppresses gastric acid secretion by blocking parietal cell H+/K+-ATPase, neutralizing the risk of NSAID-induced gastric ulceration, erosions, and GI bleeding. Indicated for chronic arthritis pain, osteoarthritis, and ankylosing spondylitis in patients with high gastrointestinal risk.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally 1 capsule once daily in the morning, 30 minutes before breakfast with a glass of water. Swallow whole; do NOT crush, chew, or open the capsule pellets.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Mild dyspepsia, diarrhea, nausea, headache, dizziness, flatulence. Rare/Severe: Gastrointestinal bleeding, cardiovascular thrombotic events, acute interstitial nephritis, and hepatotoxicity.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Contraindicated in active peptic ulcer disease, severe heart failure, CABG surgery, and third-trimester pregnancy. Rabeprazole reduces GI ulcer risk but does not eliminate cardiovascular or renal NSAID risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or analgesic treatment guidance. Always consult a registered physician or orthopedic specialist before taking pain relievers, anti-inflammatory medications, or anti-arthritic therapies.
Aceclofenac 100mg + Paracetamol 325mg Tablets
Paracetamol / Acetaminophen (Tablets 500mg, 650mg, 1000mg; Oral Suspension 120mg, 125mg, 250mg per 5ml; Drops 100mg/ml) is a first-line non-opioid analgesic and antipyretic on the WHO Model List of Essential Medicines. It selectively inhibits central prostaglandin synthesis through peroxidase-dependent inhibition of COX enzymes in the brain and spinal cord, activates descending serotonergic inhibitory pathways, and resets the hypothalamic thermoregulatory center to reduce fever through cutaneous vasodilation and sweating. Unlike NSAIDs, it does NOT inhibit peripheral cyclooxygenase, causing zero gastric mucosal ulceration, platelet dysfunction, or renal vasoconstriction. Indicated as first-line therapy for mild-to-moderate pain (headache, toothache, dysmenorrhea, osteoarthritis) and fever of diverse etiologies.
Aceclofenac Tablets 100 mg
Aceclofenac Tablets (100mg, 200mg Sustained Release) is an oral phenylacetic acid-derivative non-steroidal anti-inflammatory drug (NSAID) on the WHO Model List framework. It exhibits preferential inhibition of the COX-2 isoenzyme over COX-1, dramatically reducing synthesis of pro-inflammatory cytokines (IL-1beta, TNF-alpha) and PGE2, while stimulating synthesis of extracellular cartilage matrix components (glycosaminoglycans) in articular cartilage. Indicated for symptomatic relief of pain and inflammation in osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute musculoskeletal pain.
Rabeprazole 20mg (Enteric Coated) + Domperidone 30mg (Sustained Release) Capsules
Rabeprazole Sodium (20mg enteric-coated) and Domperidone (10mg/30mg sustained-release) is a rapid-onset PPI and prokinetic combination. Rabeprazole has a higher pKa (~5.0) than other PPIs, allowing faster activation at higher pH and achieving rapid, potent inhibition of gastric H+/K+-ATPase pumps from the first dose. Domperidone provides dopamine D2 antagonism to enhance lower esophageal sphincter tone and accelerate gastric emptying. Indicated for erosive esophagitis, GERD, hypersecretory conditions, and dyspeptic symptom complexes (nausea, postprandial fullness, acid regurgitation).
Rabeprazole Gastro Resistant Tablets 20 mg
Rabeprazole Gastro-Resistant Tablets (20mg) is a second-generation proton pump inhibitor on the WHO Model List of Essential Medicines. It binds to gastric H+/K+-ATPase with high potency and dissociates more rapidly than first-generation PPIs, producing faster acid inhibition within hours of the first dose. Indicated for acute duodenal and gastric ulcers, gastroesophageal reflux disease (GERD), erosive esophagitis, and Zollinger-Ellison syndrome.