Severe Aplastic Anemia & Hematology

Eltrombopag Tablets (25mg, 50mg) is an oral, non-peptide thrombopoietin (TPO) receptor agonist on the WHO Model List of Essential Medicines. It interacts with the transmembrane domain of the human TPO receptor (c-Mpl) on megakaryocytes and hematopoietic stem cells, initiating JAK/STAT and MAPK signaling pathways that stimulate megakaryocyte proliferation and differentiation, elevating platelet counts. Indicated for chronic immune thrombocytopenia (ITP) in patients who have had an insufficient response to corticosteroids or immunoglobulins, severe aplastic anemia, and thrombocytopenia in patients with chronic hepatitis C to allow interferon therapy.

Eltrombopag Tablets (25mg, 50mg) is an oral, non-peptide thrombopoietin (TPO) receptor agonist on the WHO Model List of Essential Medicines. It interacts with the transmembrane domain of the human TPO receptor (c-Mpl) on megakaryocytes and hematopoietic stem cells, initiating JAK/STAT and MAPK signaling pathways that stimulate megakaryocyte proliferation and differentiation, elevating platelet counts. Indicated for chronic immune thrombocytopenia (ITP) in patients who have had an insufficient response to corticosteroids or immunoglobulins, severe aplastic anemia, and thrombocytopenia in patients with chronic hepatitis C to allow interferon therapy.

Filgrastim Injection (300mcg / 30 million units per 1ml pre-filled syringe/vial) is a recombinant human granulocyte colony-stimulating factor (r-metHuG-CSF) on the WHO Model List of Essential Medicines. Produced by recombinant DNA technology in E. coli, it binds to specific cell-surface G-CSF receptors on hematopoietic progenitor cells in the bone marrow, stimulating the proliferation, differentiation, and survival of neutrophils, as well as enhancing their phagocytic and bactericidal functions. Indicated to decrease the incidence of infection (febrile neutropenia) in patients with non-myeloid malignancies receiving myelosuppressive anti-cancer drugs, acute myeloid leukemia post-chemotherapy, and mobilization of peripheral blood progenitor cells for stem cell transplantation.