TabletsClinical Overview
Amitriptyline Hydrochloride is a prototype dibenzocycloheptadiene tricyclic antidepressant (TCA) on the WHO Model List of Essential Medicines. It inhibits the presynaptic neuronal reuptake of norepinephrine and serotonin, while also antagonizing muscarinic, histaminergic H1, and alpha-1 adrenergic receptors, and blocking neuronal sodium channels. Indicated for major depressive disorder, neuropathic pain (diabetic neuropathy, post-herpetic neuralgia), chronic tension-type headache and migraine prophylaxis, and nocturnal enuresis in children.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally with water, preferably as a single dose at bedtime due to significant sedative effects. Start with a low dose and titrate gradually as prescribed. Do not stop abruptly.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Sedation, dry mouth, blurred vision, constipation, weight gain, dizziness, urinary retention, orthostatic hypotension. Rare/Severe: Cardiotoxicity (QT prolongation, arrhythmias, heart block, sudden cardiac death in overdose), paralytic ileus, seizures, and mania switch.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Black box warning for suicidality in young adults. Contraindicated during acute recovery after myocardial infarction, in cardiac arrhythmias, heart block, and concurrent MAOIs. Highly toxic in overdose; prescribe restricted quantities in suicidal patients. Caution in glaucoma and prostatic hypertrophy.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified pharmacist before initiating, modifying, or substituting any medication regimen.
Amitriptyline Hydrochloride Tablets 10mg
Amitriptyline Hydrochloride is a prototype dibenzocycloheptadiene tricyclic antidepressant (TCA) on the WHO Model List of Essential Medicines. It inhibits the presynaptic neuronal reuptake of norepinephrine and serotonin, while also antagonizing muscarinic, histaminergic H1, and alpha-1 adrenergic receptors, and blocking neuronal sodium channels. Indicated for major depressive disorder, neuropathic pain (diabetic neuropathy, post-herpetic neuralgia), chronic tension-type headache and migraine prophylaxis, and nocturnal enuresis in children.
Gabapentin 300mg + Amitriptyline 10mg Tablets
Gabapentin (300mg) and Amitriptyline (10mg) Tablets combines an alpha-2-delta calcium channel ligand with a tricyclic antidepressant. Gabapentin reduces excitatory neurotransmitter release, while amitriptyline potentiates descending serotonergic/noradrenergic inhibitory pain pathways. Indicated for chronic refractory neurogenic cough, post-herpetic neuralgia, and neuropathic pain syndromes.
Chlordiazepoxide 5mg + Amitriptyline Hydrochloride 12.5mg Tablets
Chlordiazepoxide and Amitriptyline is a classic psychotropic formulation combining a benzodiazepine with a tricyclic antidepressant (TCA). Chlordiazepoxide provides prompt reduction of psychic tension, anxiety, and agitation via GABAA receptor enhancement, while amitriptyline inhibits the neuronal reuptake of norepinephrine and serotonin to resolve underlying depressive illness. Indicated for moderate-to-severe depression associated with prominent anxiety, agitation, and insomnia.
Amitriptyline Hydrochloride Tablets 75 mg
Amitriptyline Hydrochloride is a prototype dibenzocycloheptadiene tricyclic antidepressant (TCA) on the WHO Model List of Essential Medicines. It inhibits the presynaptic neuronal reuptake of norepinephrine and serotonin, while also antagonizing muscarinic, histaminergic H1, and alpha-1 adrenergic receptors, and blocking neuronal sodium channels. Indicated for major depressive disorder, neuropathic pain (diabetic neuropathy, post-herpetic neuralgia), chronic tension-type headache and migraine prophylaxis, and nocturnal enuresis in children.