TabletsClinical Overview
Promethazine Tablets (25mg) and Syrup (5mg/5ml) is an oral first-generation H1-antihistamine with powerful antiemetic, anti-vertigo, and sedative actions on the WHO Model List of Essential Medicines. It competitively antagonizes H1 receptors, muscarinic receptors, and CTZ dopamine receptors. Indicated for prevention and treatment of motion sickness, nausea and vomiting, vertigo, urticaria, and as a nighttime sedative for allergic insomnia.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
For motion sickness: Take 25 mg 30 to 60 minutes before travel, repeated in 8 to 12 hours if needed. For nausea/vomiting: Take 25 mg every 4 to 6 hours as prescribed. For sedation: Take 25 mg at bedtime with water. Can be taken with food or milk to minimize gastric upset.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Significant drowsiness, dry mouth, blurred vision, urinary retention, constipation, lightheadedness. Rare/Severe: Respiratory depression, paradoxical excitation in children, extrapyramidal symptoms, and blood dyscrasias.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Black Box Warning: Strictly contraindicated in children under 2 years of age due to potential fatal respiratory depression. Causes profound somnolence; do not operate vehicles or machinery. Contraindicated in narrow-angle glaucoma and prostatic hypertrophy.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or gastrointestinal treatment recommendations. Always consult a registered gastroenterologist or qualified medical practitioner before initiating, altering, or discontinuing any gastrointestinal medication or digestive therapy.
Promethazine Syrup 5mg per 5ml
Promethazine Tablets (25mg) and Syrup (5mg/5ml) is an oral first-generation H1-antihistamine with powerful antiemetic, anti-vertigo, and sedative actions on the WHO Model List of Essential Medicines. It competitively antagonizes H1 receptors, muscarinic receptors, and CTZ dopamine receptors. Indicated for prevention and treatment of motion sickness, nausea and vomiting, vertigo, urticaria, and as a nighttime sedative for allergic insomnia.
Promethazine Injection 25 mg per ml
Promethazine Injection (25mg/ml) is a parenteral phenothiazine derivative first-generation H1-antihistamine with potent central antiemetic, sedative, and anticholinergic properties on the WHO Model List of Essential Medicines. It blocks histamine H1 receptors and dopamine D2 receptors in the chemoreceptor trigger zone and vestibular apparatus. Indicated for active treatment and prevention of severe nausea and vomiting, motion sickness, preoperative sedation, and acute allergic reactions.