InjectionClinical Overview
Promethazine Injection (25mg/ml) is a parenteral phenothiazine derivative first-generation H1-antihistamine with potent central antiemetic, sedative, and anticholinergic properties on the WHO Model List of Essential Medicines. It blocks histamine H1 receptors and dopamine D2 receptors in the chemoreceptor trigger zone and vestibular apparatus. Indicated for active treatment and prevention of severe nausea and vomiting, motion sickness, preoperative sedation, and acute allergic reactions.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Administer by deep intramuscular (IM) injection only. Intravenous (IV) administration must be avoided or performed with extreme caution (diluted to <=25 mg/mL, infused slowly into a running IV line) due to severe risk of chemical thrombophlebitis and gangrene. Strictly contraindicated for intra-arterial or subcutaneous injection.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Heavy sedation, drowsiness, dry mouth, blurred vision, dizziness, hypotension. Rare/Severe: Severe tissue injury, gangrene, and necrosis from accidental intra-arterial or perivascular extravasation; respiratory depression; and neuroleptic malignant syndrome.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Black Box Warning: Severe tissue injury and necrosis with parenteral extravasation. Black Box Warning: Strictly contraindicated in children under 2 years of age due to fatal respiratory depression. Avoid concurrent CNS depressants.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or gastrointestinal treatment recommendations. Always consult a registered gastroenterologist or qualified medical practitioner before initiating, altering, or discontinuing any gastrointestinal medication or digestive therapy.
Promethazine Syrup 5mg per 5ml
Promethazine Tablets (25mg) and Syrup (5mg/5ml) is an oral first-generation H1-antihistamine with powerful antiemetic, anti-vertigo, and sedative actions on the WHO Model List of Essential Medicines. It competitively antagonizes H1 receptors, muscarinic receptors, and CTZ dopamine receptors. Indicated for prevention and treatment of motion sickness, nausea and vomiting, vertigo, urticaria, and as a nighttime sedative for allergic insomnia.
Promethazine Tablets 25 mg
Promethazine Tablets (25mg) and Syrup (5mg/5ml) is an oral first-generation H1-antihistamine with powerful antiemetic, anti-vertigo, and sedative actions on the WHO Model List of Essential Medicines. It competitively antagonizes H1 receptors, muscarinic receptors, and CTZ dopamine receptors. Indicated for prevention and treatment of motion sickness, nausea and vomiting, vertigo, urticaria, and as a nighttime sedative for allergic insomnia.