TabletsClinical Overview
Nortriptyline Hydrochloride is a secondary amine tricyclic antidepressant and the active demethylated metabolite of amitriptyline. It selectively inhibits the reuptake of norepinephrine over serotonin, offering effective antidepressant and neuropathic analgesia with significantly less sedation, anticholinergic burden, and orthostatic hypotension than amitriptyline. Indicated for major depressive disorder and chronic neuropathic pain syndromes.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally at bedtime with water, with or without food. Titrate gradually based on clinical response and tolerability. Taper slowly when discontinuing.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Dry mouth, constipation, drowsiness, blurred vision, dizziness, tachycardia. Rare/Severe: Cardiac conduction abnormalities, myocardial infarction, seizures, bone marrow depression, and suicidality.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Boxed warning for suicidality. Contraindicated in post-myocardial infarction recovery and concurrent MAOIs. Caution in cardiovascular disorders, glaucoma, and urinary retention.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified pharmacist before initiating, modifying, or substituting any medication regimen.
Nortriptyline Tablets 25mg
Nortriptyline Hydrochloride is a secondary amine tricyclic antidepressant and the active demethylated metabolite of amitriptyline. It selectively inhibits the reuptake of norepinephrine over serotonin, offering effective antidepressant and neuropathic analgesia with significantly less sedation, anticholinergic burden, and orthostatic hypotension than amitriptyline. Indicated for major depressive disorder and chronic neuropathic pain syndromes.
Gabapentin 400mg + Nortriptyline 10mg Tablets
Gabapentin and Nortriptyline is a dual-acting neuropathic pain formulation combining a gabapentinoid with a tricyclic antidepressant. Gabapentin decreases excitatory neurotransmitter exocytosis by binding to alpha-2-delta subunits of voltage-gated calcium channels, while nortriptyline blocks presynaptic reuptake of noradrenaline and serotonin, reinforcing endogenous descending spinal analgesia. Indicated for diabetic peripheral neuropathy, post-herpetic neuralgia, and chronic radiculopathy.
Pregabalin 75mg + Nortriptyline 10mg Tablets
Pregabalin and Nortriptyline combines a gabapentinoid voltage-gated calcium channel modulator with a tricyclic antidepressant (TCA). Pregabalin binds the alpha-2-delta auxiliary subunit of presynaptic voltage-gated calcium channels in the CNS, diminishing calcium influx and the exocytosis of excitatory neurotransmitters (glutamate, substance P, noradrenaline). Nortriptyline inhibits presynaptic reuptake of serotonin and noradrenaline, enhancing descending inhibitory pain pathways in the spinal dorsal horn. Indicated for moderate-to-severe neuropathic pain, diabetic peripheral neuropathy, and post-herpetic neuralgia.
Pregabalin 75 mg + Methylcobalamin 1500 mcg + Nortriptyline 10 mg Tablets
Pregabalin and Nortriptyline combines a gabapentinoid voltage-gated calcium channel modulator with a tricyclic antidepressant (TCA). Pregabalin binds the alpha-2-delta auxiliary subunit of presynaptic voltage-gated calcium channels in the CNS, diminishing calcium influx and the exocytosis of excitatory neurotransmitters (glutamate, substance P, noradrenaline). Nortriptyline inhibits presynaptic reuptake of serotonin and noradrenaline, enhancing descending inhibitory pain pathways in the spinal dorsal horn. Indicated for moderate-to-severe neuropathic pain, diabetic peripheral neuropathy, and post-herpetic neuralgia.