TabletsClinical Overview
Pregabalin and Nortriptyline combines a gabapentinoid voltage-gated calcium channel modulator with a tricyclic antidepressant (TCA). Pregabalin binds the alpha-2-delta auxiliary subunit of presynaptic voltage-gated calcium channels in the CNS, diminishing calcium influx and the exocytosis of excitatory neurotransmitters (glutamate, substance P, noradrenaline). Nortriptyline inhibits presynaptic reuptake of serotonin and noradrenaline, enhancing descending inhibitory pain pathways in the spinal dorsal horn. Indicated for moderate-to-severe neuropathic pain, diabetic peripheral neuropathy, and post-herpetic neuralgia.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally once daily at bedtime with a glass of water, with or without food. Bedtime dosing helps manage somnolence and anticholinergic drowsiness. Do not discontinue abruptly; taper gradually under medical direction.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Somnolence, dry mouth, dizziness, weight gain, blurred vision, constipation, urinary hesitancy. Rare/Severe: Suicidal ideation, cardiac arrhythmias, orthostatic hypotension, angioedema, and serotonin syndrome.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Contraindicated during acute recovery phase following myocardial infarction and concomitant use of MAO inhibitors. Caution in elderly patients, cardiac conduction defects, narrow-angle glaucoma, and urinary retention. Avoid alcohol consumption.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified pharmacist before initiating, modifying, or substituting any medication regimen.
Pregabalin Capsules 75 mg
Pregabalin is an analogue of gamma-aminobutyric acid (GABA) that acts as a potent ligand at the alpha-2-delta auxiliary subunit of presynaptic voltage-gated calcium channels in the central nervous system. By reducing calcium influx into hyper-excited neurons, it curbs the pathological release of glutamate, substance P, and calcitonin gene-related peptide. Indicated for neuropathic pain associated with diabetic peripheral neuropathy, post-herpetic neuralgia, fibromyalgia, generalized anxiety disorder (GAD), and adjunctive therapy for partial-onset seizures.
Methylcobalamin Injection 500 mcg
Methylcobalamin Injection (500mcg/ml, 1500mcg/ml) is a parenteral coenzyme form of vitamin B12 on the WHO Model List framework. Bypasses intestinal intrinsic factor absorption barriers to replenish intracellular cobalamin pools, promoting neuronal myelin sheath synthesis, axonal regeneration, and methionine synthase remethylation of homocysteine. Indicated for severe peripheral neuropathy, diabetic neuropathy, megaloblastic anemia, subacute combined degeneration of the spinal cord, and pernicious anemia.
Pregabalin 75mg + Methylcobalamin 750mcg Tablets
Pregabalin is an analogue of gamma-aminobutyric acid (GABA) that acts as a potent ligand at the alpha-2-delta auxiliary subunit of presynaptic voltage-gated calcium channels in the central nervous system. By reducing calcium influx into hyper-excited neurons, it curbs the pathological release of glutamate, substance P, and calcitonin gene-related peptide. Indicated for neuropathic pain associated with diabetic peripheral neuropathy, post-herpetic neuralgia, fibromyalgia, generalized anxiety disorder (GAD), and adjunctive therapy for partial-onset seizures.
Pregabalin Tablets 75 mg
Pregabalin is an analogue of gamma-aminobutyric acid (GABA) that acts as a potent ligand at the alpha-2-delta auxiliary subunit of presynaptic voltage-gated calcium channels in the central nervous system. By reducing calcium influx into hyper-excited neurons, it curbs the pathological release of glutamate, substance P, and calcitonin gene-related peptide. Indicated for neuropathic pain associated with diabetic peripheral neuropathy, post-herpetic neuralgia, fibromyalgia, generalized anxiety disorder (GAD), and adjunctive therapy for partial-onset seizures.