TabletsMRP Under Process
Official PMBI MRP is being updated for catalog code 2043.
Locate Jan Aushadhi KendraClinical Overview
Domperidone (10mg) and Paracetamol (325mg) Tablets is a fixed-dose antiemetic and analgesic-antipyretic combination. Paracetamol provides centrally mediated analgesia and antipyresis via prostaglandin synthesis inhibition, while domperidone accelerates gastric emptying through peripheral dopamine D2 antagonism, counteracting migraine-induced gastric stasis and enhancing the absorption and therapeutic onset of paracetamol. Indicated for acute relief of headache, migraine attacks accompanied by nausea or vomiting, and febrile conditions with gastric fullness.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally with a glass of water at the onset of migraine or fever symptoms. May take up to 3 times daily as needed, maintaining at least a 6-hour interval between doses. Take on an empty stomach for faster migraine relief.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Dry mouth, drowsiness, headache, abdominal cramps, mild diarrhea. Rare/Severe: Hepatotoxicity with paracetamol overdose, QTc prolongation/ventricular arrhythmias (domperidone), and hyperprolactinemia.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Do not exceed 4 grams of paracetamol daily from all sources to avoid severe hepatotoxicity. Contraindicated in patients with severe hepatic failure, cardiac conduction abnormalities, or gastrointestinal bleeding.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or gastrointestinal treatment recommendations. Always consult a registered gastroenterologist or qualified medical practitioner before initiating, altering, or discontinuing any gastrointestinal medication or digestive therapy.
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