Clinical Overview
Levosulpiride Tablets (25mg, 50mg, 75mg) is the pure levorotatory (S)-enantiomer of sulpiride, acting as a selective dopamine D2 receptor antagonist and 5-HT4 receptor agonist. In the gastrointestinal tract, it increases lower esophageal sphincter tone and accelerates gastric emptying; centrally, it modulates mood and relieves visceral pain. Indicated for functional dyspepsia (postprandial distress syndrome), diabetic gastroparesis, and gastroesophageal reflux disease unresponsive to standard prokinetics.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally 20 to 30 minutes before meals with water, usually 25 mg three times daily. Swallow whole.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Somnolence, fatigue, amenorrhea, galactorrhea, gynecomastia, weight gain, abdominal cramping. Rare/Severe: Extrapyramidal symptoms (acute dystonia, parkinsonian tremors), tardive dyskinesia, and neuroleptic malignant syndrome.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Contraindicated in mechanical bowel obstruction, GI perforation, pheochromocytoma, and epilepsy. Avoid long-term continuous therapy without monitoring for motor or neurological side effects.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or gastrointestinal treatment recommendations. Always consult a registered gastroenterologist or qualified medical practitioner before initiating, altering, or discontinuing any gastrointestinal medication or digestive therapy.