InjectionClinical Overview
Diclofenac Sodium Injection (25mg/ml, 75mg/3ml) is a parenteral phenylacetic acid NSAID on the WHO Model List of Essential Medicines. It potently inhibits COX-1 and COX-2 enzymes to block prostaglandin synthesis. Indicated for acute severe pain, renal colic, biliary colic, acute postoperative pain, and severe trauma.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Administer by deep intragluteal intramuscular (IM) injection only, into the upper outer quadrant of the buttock (75 mg once or twice daily for a maximum of 2 days). Switch to oral therapy as soon as possible. Can also be given by slow IV infusion diluted in 100-500 mL 0.9% NaCl or 5% Dextrose buffered with sodium bicarbonate.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Injection site pain, induration, nausea, epigastric discomfort. Rare/Severe: Nicolau syndrome (severe tissue necrosis and livedoid dermatitis from accidental intra-arterial or perivascular injection), acute renal failure, and anaphylactoid shock.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Black Box Warning: For deep IM gluteal injection ONLY; rotate injection sites. Accidental injection near the sciatic nerve or into vessels causes severe Nicolau syndrome and permanent nerve damage. Contraindicated in active GI bleeding, severe heart failure, and CABG surgery. Maximum duration: 2 days.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or analgesic treatment guidance. Always consult a registered physician or orthopedic specialist before taking pain relievers, anti-inflammatory medications, or anti-arthritic therapies.
Chlorzoxazone 500mg + Diclofenac 50mg + Paracetamol 325mg Tablets
Paracetamol (325mg/500mg) and Chlorzoxazone (250mg) Tablets is a centrally acting skeletal muscle relaxant and analgesic combination. Chlorzoxazone inhibits multi-synaptic reflex arcs in the spinal cord and subcortical areas of the brain, relieving painful skeletal muscle spasms. Paracetamol acts centrally to alleviate associated pain and discomfort. Indicated for acute, painful musculoskeletal conditions, muscle spasms, lumbago, torticollis, and strain/sprain trauma.
Diclofenac Gel 1.16% (Diclofenac Diethylamine)
Diclofenac Gel 1.16% (Diclofenac Diethylamine) is an evidence-based dermatological formulation. It acts by delivering targeted active therapeutic ingredients to cutaneous lesions to relieve skin pathology, restore barrier integrity, and manage dermatoses.
Serratiopeptidase 10mg + Diclofenac Sodium 50mg Tablets
Diclofenac Sodium/Potassium Tablets (50mg Gastro-Resistant, 75mg/100mg Prolonged Release) is an oral phenylacetic acid non-steroidal anti-inflammatory drug (NSAID) on the WHO Model List of Essential Medicines. It potently inhibits both cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes, halting prostaglandin synthesis, and also reduces intracellular concentrations of free arachidonic acid in leukocytes. Potassium salt provides rapid dissolution and quick pain relief; sodium prolonged-release provides steady 24-hour therapeutic coverage. Indicated for relief of pain and inflammation in osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute musculoskeletal disorders, and acute migraine attacks.
Diclofenac Sodium Prolonged Release Tablets 100 mg
Diclofenac Sodium/Potassium Tablets (50mg Gastro-Resistant, 75mg/100mg Prolonged Release) is an oral phenylacetic acid non-steroidal anti-inflammatory drug (NSAID) on the WHO Model List of Essential Medicines. It potently inhibits both cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes, halting prostaglandin synthesis, and also reduces intracellular concentrations of free arachidonic acid in leukocytes. Potassium salt provides rapid dissolution and quick pain relief; sodium prolonged-release provides steady 24-hour therapeutic coverage. Indicated for relief of pain and inflammation in osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute musculoskeletal disorders, and acute migraine attacks.