InjectionClinical Overview
Oxaliplatin Injection (50mg) is a third-generation diaminocyclohexane (DACH) platinum antineoplastic on the WHO Model List of Essential Medicines. The bulky DACH ring forms platinum-DNA adducts that circumvent standard mismatch repair mechanisms and overcome cross-resistance to cisplatin and carboplatin. Indicated in combination with infusional 5-FU/leucovorin (FOLFOX regimen) for adjuvant treatment of stage III colon cancer, metastatic colorectal cancer, and pancreatic adenocarcinoma.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Administer intravenously only over 2 to 6 hours diluted strictly in 5% Dextrose Injection (5% Dextrose ONLY; NEVER mix with normal saline or alkaline solutions, which cause rapid drug precipitation). Premedicate with antiemetics.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Acute neurosensory toxicity (transient peripheral paresthesias and pharyngolaryngeal dysesthesia triggered by exposure to cold liquids, ice, or cold air), cumulative chronic sensory neuropathy, diarrhea, nausea, fatigue, thrombocytopenia. Rare/Severe: Anaphylaxis, pulmonary fibrosis, and posterior reversible encephalopathy syndrome (PRES).
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Black Box Warning: Cold-induced pharyngolaryngeal dysesthesia (sensation of choking or inability to breathe); strictly counsel patients to avoid cold drinks, ice, and cold ambient exposure for 48 hours following infusion. Black Box Warning: Anaphylactic reactions. NEVER dilute with sodium chloride solutions.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, oncological diagnosis, or chemotherapy protocol guidance. Cancer therapies require specialized administration under the direct supervision of a registered medical oncologist in an accredited healthcare facility.