Oxaliplatin

Active pharmaceutical substance formulated in Jan Aushadhi generic products for Oncology & Critical Care treatment.

🧴 Clinical Application

Administer intravenously only over 2 to 6 hours diluted strictly in 5% Dextrose Injection (5% Dextrose ONLY; NEVER mix with normal saline or alkaline solutions, which cause rapid drug precipitation). Premedicate with antiemetics.

⚠️ Side Effects

Common: Acute neurosensory toxicity (transient peripheral paresthesias and pharyngolaryngeal dysesthesia triggered by exposure to cold liquids, ice, or cold air), cumulative chronic sensory neuropathy, diarrhea, nausea, fatigue, thrombocytopenia. Rare/Severe: Anaphylaxis, pulmonary fibrosis, and posterior reversible encephalopathy syndrome (PRES).

🛡️ Safety Warnings

Black Box Warning: Cold-induced pharyngolaryngeal dysesthesia (sensation of choking or inability to breathe); strictly counsel patients to avoid cold drinks, ice, and cold ambient exposure for 48 hours following infusion. Black Box Warning: Anaphylactic reactions. NEVER dilute with sodium chloride solutions.