TabletsClinical Overview
Imipramine Hydrochloride is a dibenzazepine derivative tricyclic antidepressant on the WHO Model List of Essential Medicines. It blocks the presynaptic reuptake of norepinephrine and serotonin. It is metabolized into desipramine, an active selective norepinephrine reuptake inhibitor. Indicated for major depressive disorder, panic disorder, and nocturnal enuresis in pediatric patients aged 6 years and older.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally with water, usually in divided doses or as a single bedtime dose. Take with food if stomach upset occurs. Taper gradually before stopping.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Dry mouth, constipation, drowsiness, blurred vision, orthostatic dizziness, weight gain. Rare/Severe: Cardiac arrhythmias, seizures, agranulocytosis, paralytic ileus, and suicidality.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Boxed warning for suicidality. Contraindicated in acute post-MI and with MAOIs. Exercise extreme caution in cardiovascular disease, epilepsy, and benign prostatic hypertrophy.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified pharmacist before initiating, modifying, or substituting any medication regimen.
Imipramine + Diazepam Tablet (25/2 Mg)
Diazepam and Imipramine combines a classical long-acting benzodiazepine with a tricyclic antidepressant (TCA). Imipramine blocks reuptake of norepinephrine and serotonin to treat depression, while diazepam immediately quells panic, anxiety, motor agitation, and insomnia. Indicated for depression accompanied by pronounced anxiety, agitation, or sleep architecture disruption.
Imipramine + Diazepam Tablet (25/5 Mg)
Diazepam and Imipramine combines a classical long-acting benzodiazepine with a tricyclic antidepressant (TCA). Imipramine blocks reuptake of norepinephrine and serotonin to treat depression, while diazepam immediately quells panic, anxiety, motor agitation, and insomnia. Indicated for depression accompanied by pronounced anxiety, agitation, or sleep architecture disruption.