TabletsMRP Under Process
Official PMBI MRP is being updated for catalog code 2829.
Locate Jan Aushadhi KendraClinical Overview
Zolpidem and Melatonin is a dual-mechanism sleep regulator combining a non-benzodiazepine positive allosteric modulator with the endogenous pineal chronobiotic hormone. Zolpidem binds selectively to the alpha-1 subunit of the GABAA receptor, rapidly inducing sleep onset within 15-30 minutes, while melatonin acts on MT1 and MT2 receptors in the suprachiasmatic nucleus to synchronize circadian sleep architecture and promote restful sleep maintenance. Indicated for short-term management of sleep-onset and sleep-maintenance insomnia and jet lag/circadian rhythm sleep disorders.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally with a full glass of water immediately before going to bed, or in bed. Only take if at least 7 to 8 hours of uninterrupted sleep are available before daytime activities. Do not take with or immediately after a meal, which delays sleep induction.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Drowsiness, dizziness, headache, next-day somnolence, gastrointestinal distress. Rare/Severe: Boxed warning: Complex sleep behaviors (sleepwalking, sleep-driving, preparing food while asleep with total amnesia), severe allergic reactions, and dependence.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Black box warning: Complex sleep behaviors can cause serious injury or death; discontinue immediately if sleepwalking or sleep-driving occurs. Boxed warning for dependence. Never drink alcohol with this medication.
Schedule H1 (Prescription Required - Habit Forming Warning)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified pharmacist before initiating, modifying, or substituting any medication regimen.
Zolpidem Tablets 10mg
Zolpidem Tartrate is an imidazopyridine non-benzodiazepine hypnotic agent. It binds selectively with high affinity to the alpha-1 subunit-containing GABAA receptor subtype (omega-1 receptor) in the brain, sparing alpha-2 and alpha-3 subunits, resulting in potent sleep-inducing action with minimal myorelaxant and anticonvulsant effects. Indicated for short-term treatment of insomnia characterized by difficulties with sleep initiation.
Melatonin 5mg Tablets
Melatonin is a synthetic chronobiotic hormone identical to endogenous pineal melatonin. It acts as an agonist at high-affinity G-protein coupled MT1 and MT2 receptors in the suprachiasmatic nucleus (SCN) of the hypothalamus. Activation of MT1 promotes sleep onset by dampening neuronal firing in the master circadian clock, while MT2 shifts circadian rhythm phase. Indicated for primary insomnia characterized by poor sleep quality in adults aged 55 and older, delayed sleep phase syndrome, and jet lag.
Zolpidem Tablets 5mg
Zolpidem Tartrate is an imidazopyridine non-benzodiazepine hypnotic agent. It binds selectively with high affinity to the alpha-1 subunit-containing GABAA receptor subtype (omega-1 receptor) in the brain, sparing alpha-2 and alpha-3 subunits, resulting in potent sleep-inducing action with minimal myorelaxant and anticonvulsant effects. Indicated for short-term treatment of insomnia characterized by difficulties with sleep initiation.
Melatonin + Zolpidem Tablet (3/10 Mg)
Zolpidem and Melatonin is a dual-mechanism sleep regulator combining a non-benzodiazepine positive allosteric modulator with the endogenous pineal chronobiotic hormone. Zolpidem binds selectively to the alpha-1 subunit of the GABAA receptor, rapidly inducing sleep onset within 15-30 minutes, while melatonin acts on MT1 and MT2 receptors in the suprachiasmatic nucleus to synchronize circadian sleep architecture and promote restful sleep maintenance. Indicated for short-term management of sleep-onset and sleep-maintenance insomnia and jet lag/circadian rhythm sleep disorders.