TabletsMRP Under Process
Official PMBI MRP is being updated for catalog code 2366.
Locate Jan Aushadhi KendraClinical Overview
Melatonin is a synthetic chronobiotic hormone identical to endogenous pineal melatonin. It acts as an agonist at high-affinity G-protein coupled MT1 and MT2 receptors in the suprachiasmatic nucleus (SCN) of the hypothalamus. Activation of MT1 promotes sleep onset by dampening neuronal firing in the master circadian clock, while MT2 shifts circadian rhythm phase. Indicated for primary insomnia characterized by poor sleep quality in adults aged 55 and older, delayed sleep phase syndrome, and jet lag.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Take orally 1 to 2 hours before the intended bedtime with a glass of water, with or after food. Take consistently at the same time each evening. Dim household lights after taking to optimize chronobiotic signaling.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Headache, nasopharyngitis, back pain, arthralgia, daytime somnolence, dizziness. Rare/Severe: Complex nightmares, mood changes, and mild hypotension.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
May cause drowsiness; avoid driving or operating machinery for at least 4 to 5 hours after taking. Use with caution in autoimmune disorders and hepatic impairment. Avoid alcohol consumption.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or treatment recommendations. Always consult a registered medical practitioner or qualified pharmacist before initiating, modifying, or substituting any medication regimen.
Melatonin + Zolpidem Tablet (3/10 Mg)
Zolpidem and Melatonin is a dual-mechanism sleep regulator combining a non-benzodiazepine positive allosteric modulator with the endogenous pineal chronobiotic hormone. Zolpidem binds selectively to the alpha-1 subunit of the GABAA receptor, rapidly inducing sleep onset within 15-30 minutes, while melatonin acts on MT1 and MT2 receptors in the suprachiasmatic nucleus to synchronize circadian sleep architecture and promote restful sleep maintenance. Indicated for short-term management of sleep-onset and sleep-maintenance insomnia and jet lag/circadian rhythm sleep disorders.
Melatonin + Zolpidem Tablet (3/5 Mg)
Zolpidem and Melatonin is a dual-mechanism sleep regulator combining a non-benzodiazepine positive allosteric modulator with the endogenous pineal chronobiotic hormone. Zolpidem binds selectively to the alpha-1 subunit of the GABAA receptor, rapidly inducing sleep onset within 15-30 minutes, while melatonin acts on MT1 and MT2 receptors in the suprachiasmatic nucleus to synchronize circadian sleep architecture and promote restful sleep maintenance. Indicated for short-term management of sleep-onset and sleep-maintenance insomnia and jet lag/circadian rhythm sleep disorders.