DropsClinical Overview
Latanoprost (0.005% w/v) is a synthetic prostaglandin F2-alpha isopropyl ester prodrug on the WHO Model List of Essential Medicines. Following corneal penetration, it is hydrolyzed by corneal esterases to active latanoprost acid, a selective prostanoid FP receptor agonist that remodels the extracellular matrix of the ciliary muscle, dramatically enhancing uveoscleral aqueous humor outflow without altering aqueous production. Indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma and ocular hypertension.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Instill one drop into the affected eye(s) once daily in the evening. Evening administration produces optimal 24-hour diurnal IOP lowering. If more than one topical ophthalmic drug is used, administer at least 5 minutes apart. Remove contact lenses prior to dosing.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Increased brown iris pigmentation (permanent), eyelash changes (increased length, thickness, and number of lashes), conjunctival hyperemia, punctate epithelial erosions, foreign body sensation. Rare/Severe: Cystoid macular edema (in aphakic or pseudophakic patients with torn posterior lens capsule), anterior uveitis, and reactivation of herpes simplex keratitis.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
May cause irreversible darkening of the iris color and reversible darkening and growth of eyelashes. Caution in patients with history of herpetic keratitis or uveitis. Avoid touching dropper tip to eye or eyelid to maintain sterility.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or ophthalmic treatment recommendations. Always consult a registered ophthalmologist or ENT specialist before initiating, changing, or instilling any ophthalmic or otic medication.
