SolutionMRP Under Process
Official PMBI MRP is being updated for catalog code 2582.
Locate Jan Aushadhi KendraClinical Overview
Latanoprost and Timolol Maleate ophthalmic solution is a fixed-combination ocular hypotensive therapy. Latanoprost (0.005%), a prostaglandin F2-alpha analogue, increases uveoscleral outflow of aqueous humor, while timolol (0.5%), a non-selective beta-adrenergic blocker, reduces aqueous humor production in the ciliary processes. Combining these two complementary mechanisms achieves substantial, sustained intraocular pressure (IOP) reduction. Indicated for the reduction of elevated IOP in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to topical monotherapy.
Active Pharmaceutical Ingredients
Verified Clinical References
Usage Guidelines
Instill one drop into the affected eye(s) once daily, preferably in the evening. Remove contact lenses prior to instillation and wait at least 15 minutes before reinserting. Apply gentle pressure to the tear duct (nasolacrimal occlusion) for 1-2 minutes after instillation to minimize systemic absorption. Store unopened bottles in a refrigerator (2-8°C); in-use bottles can be kept at room temperature for up to 6 weeks.
General Administration Advice: Adhere strictly to the prescribed dosage, frequency, and treatment course. For oral medications, swallow with sufficient water. Never stop antibiotics, psychiatric medications, or antihypertensives abruptly without clinical direction.
Possible Side Effects
Common: Eye irritation, stinging, conjunctival hyperemia, increased brown pigmentation of the iris (permanent), hypertrichosis/eyelash darkening and lengthening, blurred vision. Rare/Severe: Bradycardia, bronchospasm, heart block, macular edema in aphakic patients, and uveitis.
*Note: Individual physiological responses vary. While many patients experience few or no side effects, notify your treating physician if adverse reactions persist or if hypersensitivity (angioedema, skin rash, dyspnea) occurs.
Precautions & Warnings
Permanent iris color change (increased brown pigmentation) may occur; inform patients before initiation. Timolol component is systemically absorbed; contraindicated in bronchial asthma, severe COPD, sinus bradycardia, second- or third-degree AV block, and overt heart failure.
Schedule H (Prescription Required)
This medication is scheduled under statutory drug regulatory frameworks (CDSCO / Drugs & Cosmetics Rules). Dispensing requires a valid medical prescription from a registered medical practitioner. Self-medication or unsupervised dosage adjustment carries significant clinical risks.
Medical Disclaimer: Statutory Clinical Disclaimer: The information provided is for educational and price-transparency purposes only and does not constitute medical advice, clinical diagnosis, or ophthalmic treatment recommendations. Always consult a registered ophthalmologist or ENT specialist before initiating, changing, or instilling any ophthalmic or otic medication.
Timolol Maleate Eye Drops 0.5 %
Timolol Maleate (0.5% w/v) is a non-selective beta-1 and beta-2 adrenergic receptor antagonist on the WHO Model List of Essential Medicines. It blocks beta-adrenergic receptors on non-pigmented ciliary epithelial cells, inhibiting cyclic AMP synthesis and reducing aqueous humor secretion by 30-50% without altering pupillary size or accommodation. Indicated for lowering elevated intraocular pressure in patients with chronic open-angle glaucoma and ocular hypertension.
Brimonidine Tartrate 0.2%w/v + Timolol Maleate 0.5%w/v Ophthalmic Solution
Timolol Maleate (0.5% w/v) is a non-selective beta-1 and beta-2 adrenergic receptor antagonist on the WHO Model List of Essential Medicines. It blocks beta-adrenergic receptors on non-pigmented ciliary epithelial cells, inhibiting cyclic AMP synthesis and reducing aqueous humor secretion by 30-50% without altering pupillary size or accommodation. Indicated for lowering elevated intraocular pressure in patients with chronic open-angle glaucoma and ocular hypertension.
Dorzolamide 2% w/v + Timolol 0.5% w/v Eye Drops
Timolol Maleate (0.5% w/v) is a non-selective beta-1 and beta-2 adrenergic receptor antagonist on the WHO Model List of Essential Medicines. It blocks beta-adrenergic receptors on non-pigmented ciliary epithelial cells, inhibiting cyclic AMP synthesis and reducing aqueous humor secretion by 30-50% without altering pupillary size or accommodation. Indicated for lowering elevated intraocular pressure in patients with chronic open-angle glaucoma and ocular hypertension.
Bimatoprost 0.03% w/v + Timolol 0.5% w/v Ophthalmic Solution
Bimatoprost (0.01%, 0.03% w/v, alone or with Timolol 0.5%) is a synthetic prostamide (cyclopentane amide) ocular hypotensive agent on the WHO Model List of Essential Medicines. It structurally mimics endogenous prostamides, binding to unique prostamide receptors to simultaneously increase both trabecular meshwork and uveoscleral aqueous humor outflow, achieving powerful intraocular pressure reduction. Indicated for the reduction of elevated intraocular pressure in open-angle glaucoma and ocular hypertension.